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Histone Deacetylase 5 (HDAC5) (AA 330-429) antibody

Details for Product No. ABIN393805, Supplier: Log in to see
Antigen
  • AI426555
  • ATHDA5
  • DKFZp459O115
  • HD5
  • Hd6
  • HDA5
  • Hdac4
  • HDAC5
  • Hdac5
  • histone deacetylase 5
  • MAF19.7
  • MAF19_7
  • mHDA1
  • mHDA2
  • mKIAA0600
  • NY-CO-9
  • Sfc6
Epitope
AA 330-429
31
22
11
9
9
8
4
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
161
68
38
6
6
2
Host
Mouse
146
15
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
3
3
3
3
Application
Immunofluorescence (IF), Western Blotting (WB)
130
90
71
24
16
16
14
3
2
2
1
Supplier
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Immunogen HDAC5 (AAH51824, 330 a.a. ~ 429 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4G2
Isotype IgG1 kappa
Specificity HDAC5 (AAH51824, 330 a.a. ~ 429 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HDAC5 (HDAC5 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 121992 DA
Gene ID 12406
Research Area Signaling, Protein Modifications, Cancer, Transcription Factors, Chromatin, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Histone Deacetylase 5 (HDAC5) (AA 330-429) antibody (ABIN393805) Immunofluorescence of monoclonal antibody to HDAC5 on HeLa cell (antibody concentrati...
Immunohistochemistry (IHC) image for anti-Histone Deacetylase 5 (HDAC5) (AA 330-429) antibody (ABIN393805) anti-Histone Deacetylase 5 (HDAC5) (AA 330-429) antibody (Image 2)
Background publications Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010

Harrison, Huynh, Lundgaard, Helmke, Perryman, McKinsey: "Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases." in: FEBS letters, Vol. 584, Issue 6, pp. 1103-10, 2010

Wang, Ha, Jhun, Wong, Jain, Jin: "Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS." in: Blood, Vol. 115, Issue 14, pp. 2971-9, 2010

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009

Rivadeneira, Styrkársdottir, Estrada, Halldórsson, Hsu, Richards, Zillikens, Kavvoura, Amin, Aulchenko, Cupples, Deloukas, Demissie, Grundberg, Hofman, Kong, Karasik, van Meurs, Oostra, Pastinen, Pols, Sigurdsson, Soranzo, Thorleifsson, Thorsteinsdottir, : "Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies." in: Nature genetics, Vol. 41, Issue 11, pp. 1199-206, 2009