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Histone Deacetylase 5 (HDAC5) (AA 330-429) antibody

Details for Product No. ABIN393805
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Antigen
Synonyms HDAC5, DKFZp459O115, HD5, NY-CO-9, AI426555, Hdac4, mHDA1, mKIAA0600, ATHDA5, HDA5, MAF19.7, MAF19_7, histone deacetylase 5, Hd6, Hdac5, Sfc6, mHDA2
Epitope
AA 330-429
(35), (23), (12), (8), (5), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(154), (102), (66), (36), (24), (24), (12)
Host
Mouse
(141), (13)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Application
Immunofluorescence (IF), Western Blotting (WB)
(117), (65), (63), (30), (28), (17), (13), (12), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393805
450.00 $
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Immunogen HDAC5 (AAH51824, 330 a.a. ~ 429 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4G2
Isotype IgG1 kappa
Specificity HDAC5 (AAH51824, 330 a.a. ~ 429 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HDAC5
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 121992 DA
Gene ID 12406
Research Area Signaling, Protein Modifications, Cancer, Transcription Factors, Chromatin, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Histone Deacetylase 5 (HDAC5) (AA 330-429) antibody Immunofluorescence of monoclonal antibody to HDAC5 on HeLa cell (antibody concentration 10 µg/mL). HDAC5 monoclonal antibody (M01), clone 4G2 Western Blot analysis of HDAC5 expression in COLO 320 HSR.
anti-Histone Deacetylase 5 (HDAC5) (AA 330-429) antibody (2) anti-Histone Deacetylase 5 (HDAC5) (AA 330-429) antibody (Image 2)
Background publications Rivadeneira, Styrkársdottir, Estrada et al.: "Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies." in: Nature genetics, Vol. 41, Issue 11, pp. 1199-206, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Wang, Ha, Jhun et al.: "Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS." in: Blood, Vol. 115, Issue 14, pp. 2971-9, 2010 (PubMed).

Harrison, Huynh, Lundgaard et al.: "Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases." in: FEBS letters, Vol. 584, Issue 6, pp. 1103-10, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
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