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CHD4 antibody (Chromodomain Helicase DNA Binding Protein 4) (AA 1632-1731)

Details for Product anti-CHD4 Antibody No. ABIN393812, Supplier: Log in to see
Antigen
  • CHD4
  • im:7143343
  • si:ch211-51m24.3
  • si:ch211-57k11.10
  • wu:fb44b12
  • wu:fd12d03
  • MGC145363
  • Mi-2b
  • Mi2-BETA
  • Mi-2
  • 9530019N15Rik
  • AA617397
  • BC005710
  • D6Ertd380e
  • Mi-2beta
  • mKIAA4075
  • b230399n07
Epitope
AA 1632-1731
4
3
3
2
2
2
2
1
1
1
1
Reactivity
Human
46
16
6
2
1
1
1
1
Host
Mouse
34
12
2
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
34
21
17
14
12
7
5
1
1
1
Supplier
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Immunogen CHD4 (NP_001264, 1632 a.a. ~ 1731 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4H4
Isotype IgG2a kappa
Specificity CHD4 (NP_001264, 1632 a.a. ~ 1731 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name CHD4 (CHD4 Antibody Abstract)
Background The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.
Synonyms: Mi2b, Mi2BETA chromodomain helicase DNA binding protein 4
Molecular Weight 217991 DA
Gene ID 1108
NCBI Accession NP_001264
Research Area Signaling, Protein Modifications, Transcription Factors, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.

Restrictions For Research Use only
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-CHD4 antibody (Chromodomain Helicase DNA Binding Protein 4) (AA 1632-1731) (ABIN393812) Western Blot analysis of CHD4 expression in transfected 293T cell line by CHD4 monocl...
Immunohistochemistry (IHC) image for anti-CHD4 antibody (Chromodomain Helicase DNA Binding Protein 4) (AA 1632-1731) (ABIN393812) anti-Chromodomain Helicase DNA Binding Protein 4 (CHD4) (AA 1632-1731) antibody (Image 2)
Background publications Li, Zhang, Yu et al.: "ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis." in: The EMBO journal, Vol. 28, Issue 18, pp. 2763-76, 2009 (PubMed).

Musselman, Mansfield, Garske et al.: "Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications." in: The Biochemical journal, Vol. 423, Issue 2, pp. 179-87, 2009 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Helbling Chadwick, Chadwick, Jaye et al.: "The Mi-2/NuRD complex associates with pericentromeric heterochromatin during S phase in rapidly proliferating lymphoid cells." in: Chromosoma, Vol. 118, Issue 4, pp. 445-57, 2009 (PubMed).

Ishii, Du, Zhang et al.: "Mi2beta shows chromatin enzyme specificity by erasing a DNase I-hypersensitive site established by ACF." in: The Journal of biological chemistry, Vol. 284, Issue 12, pp. 7533-41, 2009 (PubMed).