Retinoblastoma Binding Protein 6 (RBBP6) (AA 1582-1692) antibody

Details for Product No. ABIN393817
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Synonyms rbbp6, MGC75882, RBBP6, DYT16, PACT, RAX, MY038, P2P-R, RBQ-1, SNAMA, 4933422O15Rik, AI316869, BB233631, C030034J04Rik, C77662
AA 1582-1692
(12), (8), (5), (5), (3), (2), (2), (2), (2), (1), (1), (1)
(74), (46), (40), (1)
(67), (7)
Clonality (Clone)
Monoclonal ()
(4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Western Blotting (WB), Immunofluorescence (IF)
(40), (22), (20), (12), (9), (8), (7), (1)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen RBBP6 (NP_008841, 1582 a.a. ~ 1692 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5A11
Isotype IgG1 kappa
Specificity RBBP6 (NP_008841, 1582 a.a. ~ 1692 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name RBBP6 (RBBP6 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 201564 DA
Gene ID 12406
NCBI Accession NP_008841
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Cell Cycle, Cell Structure
Pathways Regulatory RNA Pathways
Application Notes Western blot = 1:500-1000, Immunofluorescence =10 µg/mL

Background: The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.

Restrictions For Research Use only
Concentration 1mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Retinoblastoma Binding Protein 6 (RBBP6) (AA 1582-1692) antibody (ABIN393817) Immunoperoxidase of monoclonal antibody to RBBP6 on formalin-fixed paraffin-embedded ...
Immunohistochemistry (IHC) image for anti-Retinoblastoma Binding Protein 6 (RBBP6) (AA 1582-1692) antibody (ABIN393817) anti-Retinoblastoma Binding Protein 6 (RBBP6) (AA 1582-1692) antibody (Image 2)
Background publications Stein, Hua, Lee et al.: "Voxelwise genome-wide association study (vGWAS)." in: NeuroImage, Vol. 53, Issue 3, pp. 1160-74, 2010 (PubMed).

Chibi, Meyer, Skepu et al.: "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1." in: Journal of molecular biology, Vol. 384, Issue 4, pp. 908-16, 2008 (PubMed).

Wang, Yuan, Zhou et al.: "Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways." in: Journal of proteome research, Vol. 7, Issue 9, pp. 3879-89, 2008 (PubMed).

Li, Deng, Xing et al.: "PACT is a negative regulator of p53 and essential for cell growth and embryonic development." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 19, pp. 7951-6, 2007 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Catalog No. ABIN393817
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