Retinoblastoma Binding Protein 6 (RBBP6) antibody

Details for Product No. ABIN393817
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Antigen
Synonyms MY038, P2P-R, PACT, RBQ-1, SNAMA, 4933422O15Rik, AI316869, BB233631, C030034J04Rik, C77662, rbbp6, MGC75882, RBBP6
Reactivity
Human
(52), (41), (38), (12), (12), (12), (12)
Host
Mouse
(52), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunofluorescence (IF)
(26), (20), (19), (10), (7), (5), (1)
Pubmed 5 references available
Catalog no. ABIN393817
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Immunogen RBBP6 (NP_008841, 1582 a.a. ~ 1692 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5A11
Isotype IgG1 kappa
Specificity RBBP6 (NP_008841, 1582 a.a. ~ 1692 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name RBBP6
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 201564 DA
Gene ID 12406
UniProt NP_008841
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Cell Cycle, Cell Structure
Application Notes Western blot = 1:500-1000, Immunofluorescence =10 µg/mL
Comment

Background: The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.

Restrictions For Research Use only
Concentration 1mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Retinoblastoma Binding Protein 6 (RBBP6) antibody Immunoperoxidase of monoclonal antibody to RBBP6 on formalin-fixed paraffin-embedded human testis (antibody concentration 3 µg/mL). Detection limit for recombinant GST tagged RBBP6 is approximately 0.1 ng/mL as a capture antibody.
anti-Retinoblastoma Binding Protein 6 (RBBP6) antibody (2) anti-Retinoblastoma Binding Protein 6 (RBBP6) antibody (Image 2)
Background publications Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Li, Deng, Xing et al.: "PACT is a negative regulator of p53 and essential for cell growth and embryonic development." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 19, pp. 7951-6, 2007 (PubMed).

Wang, Yuan, Zhou et al.: "Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways." in: Journal of proteome research, Vol. 7, Issue 9, pp. 3879-89, 2008 (PubMed).

Chibi, Meyer, Skepu et al.: "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1." in: Journal of molecular biology, Vol. 384, Issue 4, pp. 908-16, 2008 (PubMed).

Stein, Hua, Lee et al.: "Voxelwise genome-wide association study (vGWAS)." in: NeuroImage, Vol. 53, Issue 3, pp. 1160-74, 2010 (PubMed).

Hosts (52), (1)
Reactivities (52), (41), (38), (12), (12), (12), (12)
Applications (26), (20), (19), (10), (7), (5), (1)
Conjugates (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (5), (5), (3), (1)
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