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Lysine (K)-Specific Demethylase 2B (KDM2B) (AA 457-556) antibody

Details for Product No. ABIN393836
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Antigen
Synonyms
fb76b11, wu:fb76b11, wu:fj11c04, zgc:158441, zgc:158606, F6P23.18, F6P23_18, CXXC2, FBXL10, Fbl10, JHDM1B, PCCX2, Cxxc2, E430001G17, Fbxl10, Jhdm1b, mKIAA3014, KDM2B, fbxl10, jhdm1b, wu:fd13a09, zgc:8 ... show more
fb76b11, wu:fb76b11, wu:fj11c04, zgc:158441, zgc:158606, F6P23.18, F6P23_18, CXXC2, FBXL10, Fbl10, JHDM1B, PCCX2, Cxxc2, E430001G17, Fbxl10, Jhdm1b, mKIAA3014, KDM2B, fbxl10, jhdm1b, wu:fd13a09, zgc:85787 show less
Epitope
AA 457-556
(12), (11), (7), (2), (1), (1), (1)
Reactivity
Human
(26), (10), (5), (4), (1), (1), (1), (1)
Host
Mouse
(23), (8), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3)
Application
Immunofluorescence (IF), Western Blotting (WB)
(26), (19), (16), (4), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN393836
450.00 $
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Immunogen FBXL10 (NP_115979, 457 a.a. ~ 556 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5G1
Isotype IgG2b kappa
Specificity FBXL10 (NP_115979, 457 a.a. ~ 556 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FBXL10
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 152615 DA
Gene ID 12406
UniProt NP_115979
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Lysine (K)-Specific Demethylase 2B (KDM2B) (AA 457-556) antibody Immunofluorescence of monoclonal antibody to FBXL10 on HeLa cell (antibody concentration 10 µg/mL). FBXL10 monoclonal antibody (M09), clone 5G1 Western Blot analysis of FBXL10 expression in Hela NE.
anti-Lysine (K)-Specific Demethylase 2B (KDM2B) (AA 457-556) antibody (2) anti-Lysine (K)-Specific Demethylase 2B (KDM2B) (AA 457-556) antibody (Image 2)
Background publications Gearhart, Corcoran, Wamstad et al.: "Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets." in: Molecular and cellular biology, Vol. 26, Issue 18, pp. 6880-9, 2006 (PubMed).

Szafranski, Schindler, Taudien et al.: "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns." in: Genome biology, Vol. 8, Issue 8, pp. R154, 2008 (PubMed).

Koyama-Nasu, David, Tanese: "The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun." in: Nature cell biology, Vol. 9, Issue 9, pp. 1074-80, 2007 (PubMed).

Frescas, Guardavaccaro, Bassermann et al.: "JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes." in: Nature, Vol. 450, Issue 7167, pp. 309-13, 2007 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Validation Images
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