anti-MAGI2 antibody (Membrane Associated Guanylate Kinase, WW and PDZ Domain Containing 2) (AA 519-629)

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Synonyms MAGI2, si:dkey-97c7.1, si:dkeyp-86a5.1, ACVRIP1, AIP-1, AIP1, ARIP1, MAGI-2, SSCAM, Acvri1, Acvrinp1, Acvrip1, Magi-2, S-SCAM, mKIAA0705
AA 519-629
(6), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1)
(38), (17), (15), (1)
(29), (5), (5), (2)
Clonality (Clone)
Monoclonal ()
(33), (25), (6), (2), (1)
Pubmed 5 references available
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Quantity 0.1 mg
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Immunogen MAGI2 (NP_036433, 519 a.a. ~ 629 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6C8
Isotype IgG2a kappa
Specificity MAGI2 (NP_036433, 519 a.a. ~ 629 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MAGI2 (MAGI2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 158754 DA
Gene ID 12406
NCBI Accession NP_036433
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Pathways Neurotrophin Signaling Pathway
Application Notes ELISA ~~ 1ug/ml~3ng/ml

Background: The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-MAGI2 antibody (Membrane Associated Guanylate Kinase, WW and PDZ Domain Containing 2) (AA 519-629) (ABIN393855) Detection limit for recombinant GST tagged MAGI2 is approximately 0.03 ng/mL as a cap...
Background publications Kim, Lee, Jung et al.: "Genetic variants that affect length/height in infancy/early childhood in Vietnamese-Korean families." in: Journal of human genetics, Vol. 55, Issue 10, pp. 681-90, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Röthlisberger, Hoigné, Huber et al.: "Deletion of 7q11.21-q11.23 and infantile spasms without deletion of MAGI2." in: American journal of medical genetics. Part A, Vol. 152A, Issue 2, pp. 434-7, 2010 (PubMed).

Wolters, Alizadeh, Weijerman et al.: "Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability." in: Human immunology, Vol. 71, Issue 4, pp. 392-6, 2010 (PubMed).

Catalog No. ABIN393855
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