Membrane Associated Guanylate Kinase, WW and PDZ Domain Containing 2 (MAGI2) (AA 519-629) antibody

Details for Product No. ABIN393855
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Antigen
Synonyms MAGI2, si:dkey-97c7.1, si:dkeyp-86a5.1, ACVRIP1, AIP-1, AIP1, ARIP1, MAGI-2, SSCAM, Acvri1, Acvrinp1, Acvrip1, Magi-2, S-SCAM, mKIAA0705
Epitope
AA 519-629
(6), (3), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(34), (19), (17)
Host
Mouse
(26), (5), (4), (2)
Clonality (Clone)
Monoclonal ()
Application
ELISA
(31), (22), (5), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393855
450.00 $
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Immunogen MAGI2 (NP_036433, 519 a.a. ~ 629 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6C8
Isotype IgG2a kappa
Specificity MAGI2 (NP_036433, 519 a.a. ~ 629 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MAGI2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 158754 DA
Gene ID 12406
NCBI Accession NP_036433
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Membrane Associated Guanylate Kinase, WW and PDZ Domain Containing 2 (MAGI2) (AA 519-629) antibody Detection limit for recombinant GST tagged MAGI2 is approximately 0.03 ng/mL as a capture antibody.
Background publications Wolters, Alizadeh, Weijerman et al.: "Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability." in: Human immunology, Vol. 71, Issue 4, pp. 392-6, 2010 (PubMed).

Röthlisberger, Hoigné, Huber et al.: "Deletion of 7q11.21-q11.23 and infantile spasms without deletion of MAGI2." in: American journal of medical genetics. Part A, Vol. 152A, Issue 2, pp. 434-7, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Kim, Lee, Jung et al.: "Genetic variants that affect length/height in infancy/early childhood in Vietnamese-Korean families." in: Journal of human genetics, Vol. 55, Issue 10, pp. 681-90, 2010 (PubMed).

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