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Acetyl-CoA Carboxylase alpha antibody (ACACA) (AA 1-100)

Details for Product anti-ACACA Antibody No. ABIN393873, Supplier: Log in to see
Antigen
  • A530025K05Rik
  • Acac
  • ACAC
  • ACACAD
  • ACC
  • Acc1
  • ACC1
  • ACCA
  • acetyl-CoA carboxylase 1
  • AT-ACC1
  • EMB22
  • EMBRYO DEFECTIVE 22
  • GK
  • Gm738
  • GURKE
  • PAS3
  • PASTICCINO 3
Alternatives
anti-Human Acetyl-CoA Carboxylase alpha antibody for Western Blotting
Epitope
AA 1-100
32
20
16
15
9
9
3
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
130
57
54
6
6
4
2
1
Host
Mouse
125
9
Clonality (Clone)
Monoclonal ()
Conjugate
This Acetyl-CoA Carboxylase alpha antibody is un-conjugated
5
5
5
3
3
3
3
3
3
3
3
3
2
2
2
Application
ELISA, Western Blotting (WB)
92
45
33
33
19
7
5
2
1
1
1
Supplier
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Immunogen ACACA (NP_942131, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6H5
Isotype IgG2a kappa
Specificity ACACA (NP_942131, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ACACA (ACACA Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 265554 DA
Gene ID 12406
NCBI Accession NP_942131
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Cell Structure
Pathways AMPK Signaling
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Acetyl-CoA Carboxylase alpha antibody (ACACA) (AA 1-100) (ABIN393873) Detection limit for recombinant GST tagged ACACA is approximately 0.03 ng/mL as a cap...
Background publications Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010

Ruaño, Thompson, Kane, Pullinger, Windemuth, Seip, Kocherla, Holford, Wu: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010

Kim, Moon, Park, Cheng, Kwon, Horton: "Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 21, pp. 9626-31, 2010

Rose, Behm, Drgon, Johnson, Uhl: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010

Zhao, Iwasaki, Zhe, Nishiyama, Taguchi, Tsugita, Kambayashi, Hashimoto, Terada: "Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription." in: Endocrine journal, Vol. 57, Issue 4, pp. 317-24, 2010