Acetyl-CoA Carboxylase alpha (ACACA) (AA 1-100) antibody

Details for Product No. ABIN393873
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms AT-ACC1, EMB22, EMBRYO DEFECTIVE 22, GK, GURKE, PAS3, PASTICCINO 3, acetyl-CoA carboxylase 1, ACAC, ACACAD, ACC, ACC1, ACCA, Acac, A530025K05Rik, Acc1, Gm738
Epitope
AA 1-100
(28), (17), (15), (14), (9), (5), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(119), (52), (48), (1)
Host
Mouse
(115), (9)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Application
ELISA, Western Blotting (WB)
(89), (45), (32), (30), (18), (6), (3), (3), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Immunogen ACACA (NP_942131, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6H5
Isotype IgG2a kappa
Specificity ACACA (NP_942131, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ACACA (ACACA Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 265554 DA
Gene ID 12406
NCBI Accession NP_942131
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Acetyl-CoA Carboxylase alpha (ACACA) (AA 1-100) antibody Detection limit for recombinant GST tagged ACACA is approximately 0.03 ng/mL as a cap...
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Kim, Moon, Park et al.: "Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 21, pp. 9626-31, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Zhao, Iwasaki, Zhe et al.: "Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription." in: Endocrine journal, Vol. 57, Issue 4, pp. 317-24, 2010 (PubMed).

Validation Images
Catalog No. ABIN393873
450.00 $
Plus shipping costs $45.00
Quantity
Price
0.1 mg
450.00 $

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)
Did you look for something else?