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Acetyl-CoA Carboxylase alpha (ACACA) antibody

Details for Product No. ABIN393873
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Antigen
Synonyms ACAC, ACACAD, ACC, ACC1, ACCA, A530025K05Rik, Acac, Acc1, Gm738, AT-ACC1, EMB22, EMBRYO DEFECTIVE 22, GK, GURKE, PAS3, PASTICCINO 3, acetyl-CoA carboxylase 1
Reactivity
Human
(107), (57), (53), (24), (24), (24), (12), (12), (12), (1)
Host
Mouse
(105), (6)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(70), (46), (40), (24), (19), (7), (3), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN393873
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen ACACA (NP_942131, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 6H5
Isotype IgG2a kappa
Specificity ACACA (NP_942131, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ACACA
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 265554 DA
Gene ID 12406
UniProt NP_942131
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Acetyl-CoA Carboxylase alpha (ACACA) antibody Detection limit for recombinant GST tagged ACACA is approximately 0.03 ng/mL as a capture antibody.
Background publications Zhao, Iwasaki, Zhe et al.: "Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription." in: Endocrine journal, Vol. 57, Issue 4, pp. 317-24, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Kim, Moon, Park et al.: "Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 21, pp. 9626-31, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN393873
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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