Membrane Associated Guanylate Kinase, WW and PDZ Domain Containing 1 (MAGI1) antibody

Antigen: Membrane Associated Guanylate Kinase, WW and PDZ Domain Containing 1 (MAGI1)

Synonyms: AIP3, BAP1, WWP3, BAIAP1, MAGI-1, TNRC19, CNKSR3, MAGI1

Clonality: Monoclonal (7B4)

Host: Mouse

Reactivity: Human

Application: ELISA, Immunofluorescence (IF), Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393876

Additional Information

Alternative name: MAGI1

Gene ID: 9223

UniProt: NP_004733

Immunogen: MAGI1 (NP_004733, 761 a.a. ~ 860 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 7B4

Description: Other names: AIP3, BAIAP1, BAP1, MAGI1, TNRC19, WWP3 membrane associated guanylate kinase, WW and PDZ domain containing 1

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: MAGI1 (NP_004733, 761 a.a. ~ 860 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 164641 DA

Comments:

Background: The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Phospho-specific antibodies, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Images

Immunofluorescence of monoclonal antibody to MAGI1 (AT2763a) on HeLa cell . [antibody concentration 10 ug/ml] MAGI1 monoclonal antibody (M03), clone 7B4 Western Blot analysis of MAGI1 expression in PC-12 ( Cat # L012V1 ).

anti-Membrane Associated Guanylate Kinase, WW and PDZ Domain Containing 1 (MAGI1) antibody (Image 2)

Publications

Product: Zeggini, Scott, Saxena et al.: "Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes." in: Nature genetics, Vol. 40, Issue 5, pp. 638-45, 2008 (PubMed).

Uhl, Liu, Drgon et al.: "Molecular genetics of successful smoking cessation: convergent genome-wide association study results." in: Archives of general psychiatry, Vol. 65, Issue 6, pp. 683-93, 2008 (PubMed).

Ohnishi, Tochio, Tomizawa et al.: "Structural basis for controlling the dimerization and stability of the WW domains of an atypical subfamily." in: Protein science : a publication of the Protein Society, Vol. 17, Issue 9, pp. 1531-41, 2008 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Kaufman, Potla, Coleman et al.: "Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25677-85, 2010 (PubMed).