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A Kinase (PRKA) Anchor Protein 10 (AKAP10) (AA 1-101) antibody

Details for Product No. ABIN393884, Supplier: Log in to see
Antigen
  • MGC84612
  • AKAP10
  • fc10g11
  • wu:fc10g11
  • si:dkey-197m14.4
  • AKAP-10
  • D-AKAP-2
  • D-AKAP2
  • PRKA10
  • 1500031L16Rik
  • B130049N18Rik
  • D-akap2
  • Akap10
Epitope
AA 1-101
15
14
5
3
1
1
1
1
1
1
1
1
Reactivity
Human
55
32
21
6
4
4
2
Host
Mouse
33
29
4
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Western Blotting (WB)
48
41
13
5
3
2
1
1
1
1
Supplier
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Immunogen AKAP10 (NP_009133, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 8C10
Isotype IgG2a kappa
Specificity AKAP10 (NP_009133, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name AKAP10 (AKAP10 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 73818 DA
Gene ID 12406
NCBI Accession NP_009133
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA, therefore, it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS (regulator of G protein signalling) domains, in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-A Kinase (PRKA) Anchor Protein 10 (AKAP10) (AA 1-101) antibody (ABIN393884) Western blot analysis of AKAP10 over-expressed 293 cell line, cotransfected with AKAP...
Immunohistochemistry (IHC) image for anti-A Kinase (PRKA) Anchor Protein 10 (AKAP10) (AA 1-101) antibody (ABIN393884) anti-A Kinase (PRKA) Anchor Protein 10 (AKAP10) (AA 1-101) antibody (Image 2)
Background publications Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

Sarma, Kinderman, Kim et al.: "Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity." in: Structure (London, England : 1993), Vol. 18, Issue 2, pp. 155-66, 2010 (PubMed).

Zukowski, Bohatyrewicz, Biernawska et al.: "Association of the A1936G (rs203462) of A-kinase anchoring protein 10 polymorphisms with QT interval prolongation during kidney transplantation." in: Transplantation proceedings, Vol. 41, Issue 8, pp. 3036-8, 2009 (PubMed).

Eggers, Schafer, Goldenring et al.: "D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling." in: The Journal of biological chemistry, Vol. 284, Issue 47, pp. 32869-80, 2009 (PubMed).

Yoshida, Kato, Yokoi et al.: "Association of genetic variants with chronic kidney disease in individuals with different lipid profiles." in: International journal of molecular medicine, Vol. 24, Issue 2, pp. 233-46, 2009 (PubMed).