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CDK6 antibody (Cyclin-Dependent Kinase 6) (AA 3-100)

Details for Product anti-CDK6 Antibody No. ABIN393888, Supplier: Log in to see
Antigen
  • CDK6
  • PLSTIRE
  • 5830411I20
  • AI504062
  • Crk2
Alternatives
anti-Human CDK6 antibody for Immunohistochemistry (Frozen Sections)
Epitope
AA 3-100
30
28
24
17
7
6
5
5
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
226
99
66
3
3
1
Host
Mouse
159
70
Clonality (Clone)
Monoclonal ()
Conjugate
This CDK6 antibody is un-conjugated
6
4
4
3
2
2
2
2
2
2
2
2
2
2
2
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
153
92
74
47
43
32
24
21
13
2
2
1
1
1
Supplier
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Immunogen CDK6 (NP_001250, 3 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 8H4
Isotype IgG1 kappa
Specificity CDK6 (NP_001250, 3 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CDK6 (CDK6 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 36938 DA
Gene ID 12406
NCBI Accession NP_001250
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Cell Cycle, Cell Structure
Pathways Cell Division Cycle
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-CDK6 antibody (Cyclin-Dependent Kinase 6) (AA 3-100) (ABIN393888) Immunofluorescence of monoclonal antibody to CDK6 on HeLa cell (antibody concentratio...
Immunohistochemistry (IHC) image for anti-CDK6 antibody (Cyclin-Dependent Kinase 6) (AA 3-100) (ABIN393888) anti-Cyclin-Dependent Kinase 6 (CDK6) (AA 3-100) antibody (Image 2)
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Zhao, Li, Bradfield et al.: "The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature." in: BMC medical genetics, Vol. 11, pp. 96, 2010 (PubMed).

Wiedemeyer, Dunn, Quayle et al.: "Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 25, pp. 11501-6, 2010 (PubMed).

Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

van der Helm-van Mil, Toes, Huizinga: "Genetic variants in the prediction of rheumatoid arthritis." in: Annals of the rheumatic diseases, Vol. 69, Issue 9, pp. 1694-6, 2010 (PubMed).