Charged Multivesicular Body Protein 2B (CHMP2B) antibody

Details for Product No. ABIN393892
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Synonyms ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B, 1190006E07Rik, RGD1306781, chmp2b, chmp2bl, zgc:77025, si:ch211-224m9.5, CHMP2B
(36), (18), (16), (12), (12), (12)
(33), (3), (1)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(25), (17), (12), (10), (4), (1), (1), (1)
Pubmed 5 references available
Catalog no. ABIN393892
Quantity 0.1 mg
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Immunogen CHMP2B (AAH01553, 1 a.a. ~ 592 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone M1
Isotype IgG1 kappa
Specificity CHMP2B (AAH01553, 1 a.a. ~ 592 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CHMP2B
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 118544 DA
Gene ID 12406
Research Area Ubiquitin-related antibodies, Protein Modifications, Cell Structure, Cell Cycle
Application Notes ELISA ~~ 1ug/ml~3ng/ml

Background: This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Charged Multivesicular Body Protein 2B (CHMP2B) antibody Detection limit for recombinant GST tagged CHMP2B is approximately 0.03 ng/mL as a capture antibody.
Background publications Cox, Ferraiuolo, Goodall et al.: "Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS)." in: PLoS ONE, Vol. 5, Issue 3, pp. e9872, 2010 (PubMed).

Kaivorinne, Krüger, Udd et al.: "Mutations in CHMP2B are not a cause of frontotemporal lobar degeneration in Finnish patients." in: European journal of neurology : the official journal of the European Federation of Neurological Societies, Vol. 17, Issue 11, pp. 1393-5, 2010 (PubMed).

Yamazaki, Takahashi, Hiji et al.: "Immunopositivity for ESCRT-III subunit CHMP2B in granulovacuolar degeneration of neurons in the Alzheimer's disease hippocampus." in: Neuroscience letters, Vol. 477, Issue 2, pp. 86-90, 2010 (PubMed).

Tsai, Soong, Lin et al.: "FUS, TARDBP, and SOD1 mutations in a Taiwanese cohort with familial ALS." in: Neurobiology of aging, Vol. 32, Issue 3, pp. 553.e13-21, 2011 (PubMed).

Ghanim, Guillot-Noel, Pasquier et al.: "CHMP2B mutations are rare in French families with frontotemporal lobar degeneration." in: Journal of neurology, Vol. 257, Issue 12, pp. 2032-6, 2010 (PubMed).

Hosts (33), (3), (1)
Reactivities (36), (18), (16), (12), (12), (12)
Applications (25), (17), (12), (10), (4), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (5), (3), (2), (1)
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