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TCEB3 antibody (Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, Elongin A)) (AA 81-191)

Details for Product anti-TCEB3 Antibody No. ABIN393901, Supplier: Log in to see
Antigen
  • CG6755
  • Dmel\\CG6755
  • Elo-A
  • dEloA
  • tceb3a
  • zgc:56638
  • wu:fw66g10
  • TCEB3
  • 110kDa
  • AA408125
  • Tceb3a
  • El
  • EloA
  • SIII
  • SIII p110
  • TCEB3A
Epitope
AA 81-191
16
15
14
13
8
5
4
3
3
3
3
2
2
2
2
2
2
1
1
1
Reactivity
Human
80
17
17
2
2
1
Host
Mouse
77
7
3
Clonality (Clone)
Monoclonal ()
Conjugate
This TCEB3 antibody is un-conjugated
5
5
4
4
4
4
1
Application
Western Blotting (WB)
71
46
19
9
6
6
3
2
2
Supplier
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Immunogen TCEB3 (NP_003189, 81 a.a. ~ 191 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3E2
Isotype IgG2a kappa
Specificity TCEB3 (NP_003189, 81 a.a. ~ 191 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TCEB3 (TCEB3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 87230 DA
Gene ID 12406
NCBI Accession NP_003189
Research Area Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-TCEB3 antibody (Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, Elongin A)) (AA 81-191) (ABIN393901) Western Blot analysis of TCEB3 expression in transfected 293T cell line by TCEB3 mono...
Immunohistochemistry (IHC) image for anti-TCEB3 antibody (Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, Elongin A)) (AA 81-191) (ABIN393901) anti-Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, Elongin A) (TCEB3) (AA 81-191) antibody (Image 2)
Background publications Landa, Ruiz-Llorente, Montero-Conde et al.: "The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors." in: PLoS genetics, Vol. 5, Issue 9, pp. e1000637, 2009 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Woo, Imm, Min et al.: "Structural and functional insights into the B30.2/SPRY domain." in: The EMBO journal, Vol. 25, Issue 6, pp. 1353-63, 2006 (PubMed).