BCL2-Associated Athanogene (BAG1) (AA 241-346) antibody

Details for Product No. ABIN393902
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Antigen
Synonyms ATBAG1, BCL-2-associated athanogene 1, MSG15.15, MSG15_15, BAG-1, HAP, RAP46, Bag-1, Rap46
Epitope
AA 241-346
(17), (17), (5), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(75), (52), (40), (12), (1), (1)
Host
Mouse
(76), (11)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(74), (31), (26), (16), (12), (10), (9), (8), (3), (2), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393902
450.00 $
Plus shipping costs $45.00

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Immunogen BAG1 (NP_004314, 241 a.a. ~ 346 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4E2
Isotype IgG2a kappa
Specificity BAG1 (NP_004314, 241 a.a. ~ 346 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BAG1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 38878 DA
Gene ID 12406
NCBI Accession NP_004314
Research Area Translation Factors, Cell Structure, Signaling
Application Notes Western blot = 1:500-1000
Comment

Background: The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-BCL2-Associated Athanogene (BAG1) (AA 241-346) antibody Immunofluorescence of monoclonal antibody to BAG1 on HeLa cell (antibody concentration 10 µg/mL). BAG1 monoclonal antibody (M01), clone 4E2 Western Blot analysis of BAG1 expression in HeLa.
anti-BCL2-Associated Athanogene (BAG1) (AA 241-346) antibody (2) anti-BCL2-Associated Athanogene (BAG1) (AA 241-346) antibody (Image 2)
Background publications Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Zheng, Xu, Xing et al.: "Nuclear or cytoplasmic localization of Bag-1 distinctly correlates with pathologic behavior and outcome of gastric carcinomas." in: Human pathology, Vol. 41, Issue 5, pp. 724-36, 2010 (PubMed).

Deeg, Gralle, Sroka et al.: "BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity." in: The Journal of cell biology, Vol. 188, Issue 4, pp. 505-13, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
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