Interferon, gamma-Inducible Protein 16 (IFI16) (AA 630-730) antibody

Details for Product No. ABIN393907
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Antigen
Synonyms IFI16, Ifi16, p204, IFNGIP1, PYHIN2
Epitope
AA 630-730
(7), (7), (6), (4), (4), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(76)
Host
Mouse
(55), (21)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(53), (35), (20), (18), (7), (7), (4), (4), (2), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393907
450.00 $
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Immunogen IFI16 (AAH17059, 630 a.a. ~ 730 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E3
Isotype IgG2b kappa
Specificity IFI16 (AAH17059, 630 a.a. ~ 730 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name IFI16
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 88256 DA
Gene ID 12406
Research Area Cell Signaling, Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Interferon, gamma-Inducible Protein 16 (IFI16) (AA 630-730) antibody Immunofluorescence of monoclonal antibody to IFI16 on HeLa cell (antibody concentration 10 µg/mL). Western Blot analysis of IFI16 expression in transfected 293T cell line by IFI16 monoclonal antibody (M03), clone 2E3. Lane 1: IFI16 transfected lysate(82 KDa). Lane 2: Non-transfected lysate.
anti-Interferon, gamma-Inducible Protein 16 (IFI16) (AA 630-730) antibody (2) anti-Interferon, gamma-Inducible Protein 16 (IFI16) (AA 630-730) antibody (Image 2)
Background publications Yu, Hao, Zhao et al.: "Delta-like 1 contributes to cell growth by increasing the interferon-inducible protein 16 expression in hepatocellular carcinoma." in: Liver international : official journal of the International Association for the Study of the Liver, Vol. 30, Issue 5, pp. 703-14, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Cristea, Moorman, Terhune et al.: "Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein." in: Journal of virology, Vol. 84, Issue 15, pp. 7803-14, 2010 (PubMed).

Kimkong, Avihingsanon, Hirankarn: "Association of IFI200 gene polymorphisms with susceptibility to systemic lupus erythematosus." in: The Journal of rheumatology, Vol. 37, Issue 7, pp. 1544-7, 2010 (PubMed).

Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

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