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IFI16 antibody (Interferon, gamma-Inducible Protein 16) (AA 630-730)

Details for Product anti-IFI16 Antibody No. ABIN393907, Supplier: Log in to see
Antigen
  • IFI16
  • Ifi16
  • p204
  • IFNGIP1
  • PYHIN2
  • interferon, gamma-inducible protein 16
  • interferon activated gene 204
  • IFI16
  • Ifi204
  • Ifi16
Alternatives
anti-Human IFI16 antibody for Immunofluorescence
Epitope
AA 630-730
12
7
6
6
4
3
3
2
1
1
1
1
1
Reactivity
Human
86
4
Host
Mouse
63
23
Clonality (Clone)
Monoclonal ()
Conjugate
This IFI16 antibody is un-conjugated
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
61
33
23
18
16
13
9
2
2
1
1
1
Options
Supplier
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Immunogen IFI16 (AAH17059, 630 a.a. ~ 730 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E3
Isotype IgG2b kappa
Specificity IFI16 (AAH17059, 630 a.a. ~ 730 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name IFI16 (IFI16 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 88256 DA
Gene ID 12406
Research Area Cell Signaling, Transcription Factors, Signaling, Cell Structure
Pathways Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-IFI16 antibody (Interferon, gamma-Inducible Protein 16) (AA 630-730) (ABIN393907) Immunofluorescence of monoclonal antibody to IFI16 on HeLa cell (antibody concentrati...
Immunohistochemistry (IHC) image for anti-IFI16 antibody (Interferon, gamma-Inducible Protein 16) (AA 630-730) (ABIN393907) anti-Interferon, gamma-Inducible Protein 16 (IFI16) (AA 630-730) antibody (Image 2)
Background publications Johnatty, Beesley, Chen, Macgregor, Duffy, Spurdle, deFazio, Gava, Webb, Rossing, Doherty, Goodman, Lurie, Thompson, Wilkens, Ness, Moysich, Chang-Claude, Wang-Gohrke, Cramer, Terry, Hankinson, Tworoger, Garcia-Closas, Yang, Lissowska, Chanock, Pharoah, S: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Kimkong, Avihingsanon, Hirankarn: "Association of IFI200 gene polymorphisms with susceptibility to systemic lupus erythematosus." in: The Journal of rheumatology, Vol. 37, Issue 7, pp. 1544-7, 2010 (PubMed).

Cristea, Moorman, Terhune, Cuevas, OKeefe, Rout, Chait, Shenk: "Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein." in: Journal of virology, Vol. 84, Issue 15, pp. 7803-14, 2010 (PubMed).

Rose, Behm, Drgon, Johnson, Uhl: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Yu, Hao, Zhao, Ge, Yao, Yang, Li: "Delta-like 1 contributes to cell growth by increasing the interferon-inducible protein 16 expression in hepatocellular carcinoma." in: Liver international : official journal of the International Association for the Study of the Liver, Vol. 30, Issue 5, pp. 703-14, 2010 (PubMed).