Paired Box 2 (PAX2) (AA 194-304) antibody

Details for Product No. ABIN393911, Supplier: Log in to see
Antigen
  • PAX2
  • XPax-2
  • XPax2
  • pax-2
  • pax2
  • PAX-2
  • PAPRS
  • Opdc
  • Pax-2
  • PAXZF-B
  • cb378
  • noi
  • pax-b
  • pax2.1
  • pax2a1
  • pax[zf-b]
  • paxb
  • paired box 2
  • paired box gene 2
  • paired box gene 2a
  • paired box protein 2
  • PAX2
  • pax2-b
  • Pax2
  • pax2a
  • Pax-2
Alternatives
anti-Human Paired Box 2 antibody for ELISA
Epitope
AA 194-304
11
10
9
8
8
7
7
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
107
40
32
8
8
8
8
7
6
6
6
4
4
3
1
Host
Mouse
98
11
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
10
10
5
2
2
2
Application
Western Blotting (WB)
97
64
20
18
15
7
2
2
1
1
1
Options
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Immunogen PAX2 (NP_000269, 194 a.a. ~ 304 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E4
Isotype IgG2a kappa
Specificity PAX2 (NP_000269, 194 a.a. ~ 304 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name PAX2 (PAX2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight NONE?! DA
Gene ID 12406
NCBI Accession NP_000269
Research Area Cancer, Transcription Factors, Signaling, Cell Structure
Pathways Carbohydrate Homeostasis, Stem Cell Maintenance, Tube Formation
Application Notes Western blot = 1:500-1000
Comment

Background: PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Paired Box 2 (PAX2) (AA 194-304) antibody (ABIN393911) PAX2 monoclonal antibody (M02), clone 2E4 Western Blot analysis of PAX2 expression in...
Background publications Ozcan, Zhai, Javed, Shen, Coffey, Krishnan, Truong: "PAX-2 is a helpful marker for diagnosing metastatic renal cell carcinoma: comparison with the renal cell carcinoma marker antigen and kidney-specific cadherin." in: Archives of pathology & laboratory medicine, Vol. 134, Issue 8, pp. 1121-9, 2010 (PubMed).

Monte, Webster, Neuberg, Dressler, Mutter: "Joint loss of PAX2 and PTEN expression in endometrial precancers and cancer." in: Cancer research, Vol. 70, Issue 15, pp. 6225-32, 2010 (PubMed).

Quick, Gokden, Sangoi, Brooks, McKenney: "The distribution of PAX-2 immunoreactivity in the prostate gland, seminal vesicle, and ejaculatory duct: comparison with prostatic adenocarcinoma and discussion of prostatic zonal embryogenesis." in: Human pathology, Vol. 41, Issue 8, pp. 1145-9, 2010 (PubMed).

Rabban, McAlhany, Lerwill, Grenert, Zaloudek: "PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma." in: The American journal of surgical pathology, Vol. 34, Issue 2, pp. 137-46, 2010 (PubMed).

Cordell, Darlay, Charoen, Stewart, Gullett, Lambert, Malcolm, Feather, Goodship, Woolf, Kenda, Goodship,: "Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux." in: Journal of the American Society of Nephrology : JASN, Vol. 21, Issue 1, pp. 113-23, 2010 (PubMed).