Paired Box 2 (PAX2) antibody

Antigen: Paired Box 2 (PAX2)

Synonyms: Pax-2, PAX2

Clonality: Monoclonal (2E4)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393911

Additional Information

Alternative name: PAX2

Gene ID: 5076

UniProt: NP_000269

Immunogen: PAX2 (NP_000269, 194 a.a. ~ 304 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 2E4

Description: Other names: paired box gene 2

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: PAX2 (NP_000269, 194 a.a. ~ 304 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: NONE?! DA

Comments:

Background: PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cancer, Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Images

PAX2 monoclonal antibody (M02), clone 2E4 Western Blot analysis of PAX2 expression in PC-12 ( Cat # L012V1 ).

Publications

Product: Cordell, Darlay, Charoen et al.: "Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux." in: Journal of the American Society of Nephrology : JASN, Vol. 21, Issue 1, pp. 113-23, 2010 (PubMed).

Rabban, McAlhany, Lerwill et al.: "PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma." in: The American journal of surgical pathology, Vol. 34, Issue 2, pp. 137-46, 2010 (PubMed).

Quick, Gokden, Sangoi et al.: "The distribution of PAX-2 immunoreactivity in the prostate gland, seminal vesicle, and ejaculatory duct: comparison with prostatic adenocarcinoma and discussion of prostatic zonal embryogenesis." in: Human pathology, Vol. 41, Issue 8, pp. 1145-9, 2010 (PubMed).

Monte, Webster, Neuberg et al.: "Joint loss of PAX2 and PTEN expression in endometrial precancers and cancer." in: Cancer research, Vol. 70, Issue 15, pp. 6225-32, 2010 (PubMed).

Ozcan, Zhai, Javed et al.: "PAX-2 is a helpful marker for diagnosing metastatic renal cell carcinoma: comparison with the renal cell carcinoma marker antigen and kidney-specific cadherin." in: Archives of pathology & laboratory medicine, Vol. 134, Issue 8, pp. 1121-9, 2010 (PubMed).