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Details for Product No. ABIN393911

Paired Box 2 (PAX2) antibody

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Synonyms PAPRS, PAX-2, PAX2
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN393911
Quantity 0.1 mg
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen PAX2 (NP_000269, 194 a.a. ~ 304 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E4
Isotype IgG2a kappa
Specificity PAX2 (NP_000269, 194 a.a. ~ 304 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name PAX2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight NONE?! DA
Gene ID 12406
UniProt NP_000269
Research Area Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Cordell, Darlay, Charoen et al.: "Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux." in: Journal of the American Society of Nephrology : JASN, Vol. 21, Issue 1, pp. 113-23, 2010 (PubMed).

Rabban, McAlhany, Lerwill et al.: "PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma." in: The American journal of surgical pathology, Vol. 34, Issue 2, pp. 137-46, 2010 (PubMed).

Quick, Gokden, Sangoi et al.: "The distribution of PAX-2 immunoreactivity in the prostate gland, seminal vesicle, and ejaculatory duct: comparison with prostatic adenocarcinoma and discussion of prostatic zonal embryogenesis." in: Human pathology, Vol. 41, Issue 8, pp. 1145-9, 2010 (PubMed).

Monte, Webster, Neuberg et al.: "Joint loss of PAX2 and PTEN expression in endometrial precancers and cancer." in: Cancer research, Vol. 70, Issue 15, pp. 6225-32, 2010 (PubMed).

Ozcan, Zhai, Javed et al.: "PAX-2 is a helpful marker for diagnosing metastatic renal cell carcinoma: comparison with the renal cell carcinoma marker antigen and kidney-specific cadherin." in: Archives of pathology & laboratory medicine, Vol. 134, Issue 8, pp. 1121-9, 2010 (PubMed).

Alternatives for antigen "Paired Box 2 (PAX2)", type "Antibodies"
Hosts (53), (6), (1)
Reactivities (53), (24), (16), (14), (13), (13), (13), (1), (1), (1), (1), (1)
Applications (42), (20), (12), (10), (8), (6), (4), (2), (2), (2), (1), (1)
Conjugates (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)