Kruppel-Like Factor 12 (KLF12) (AA 1-91) antibody

Details for Product No. ABIN393913
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Antigen
Synonyms zgc:171689, KLF12, AP-2rep, AP2REP, 2700063E05Rik, AI225908, AI315654, B130052C06Rik, D530033K05Rik, fb02h07, klf12, wu:fb02h07, zgc:77286
Epitope
AA 1-91
(8), (7), (5), (3), (2), (1), (1), (1), (1)
Reactivity
Human
(26), (8), (5), (3), (1), (1)
Host
Mouse
(23), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(26), (13), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN393913
450.00 $
Plus shipping costs $45.00

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Immunogen KLF12 (NP_009180, 1 a.a. ~ 91 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3E4
Isotype IgG2a kappa
Specificity KLF12 (NP_009180, 1 a.a. ~ 91 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name KLF12
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 44240 DA
Gene ID 12406
NCBI Accession NP_009180
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Kruppel-Like Factor 12 (KLF12) (AA 1-91) antibody Western Blot analysis of KLF12 expression in transfected 293T cell line by KLF12 monoclonal antibody (M01), clone 3E4. Lane 1: KLF12 transfected lysate(44.2 KDa). Lane 2: Non-transfected lysate.
Background publications Nakamura, Migita, Hosoda et al.: "Krüppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression." in: International journal of cancer. Journal international du cancer, Vol. 125, Issue 8, pp. 1859-67, 2009 (PubMed).

Eyre, Flynn, Martin et al.: "No evidence for association of the KLF12 gene with rheumatoid arthritis in a large UK cohort." in: Annals of the rheumatic diseases, Vol. 69, Issue 7, pp. 1407-8, 2010 (PubMed).

Wieczorek, Holle, Müller et al.: "A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis." in: Journal of molecular medicine (Berlin, Germany), Vol. 88, Issue 4, pp. 413-21, 2010 (PubMed).

Petersen, Amundadottir, Fuchs et al.: "A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33." in: Nature genetics, Vol. 42, Issue 3, pp. 224-8, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Validation Images
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