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Lamin B1 (LMNB1) (AA 107-186) antibody

Details for Product No. ABIN393915
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Antigen
Synonyms MGC52550, Lamin-L(I), lamin-b, lmn, lmn2, lmnb, LMNB1, ADLD, LMN, LMN2, LMNB, fc06g01, wu:fc06g01
Epitope
AA 107-186
(11), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(60), (29), (25), (6), (5), (5), (5), (3), (2)
Host
Mouse
(44), (24), (2)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
(69), (36), (23), (18), (14), (11), (11), (9), (4), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN393915
450.00 $
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Immunogen LMNB1 (NP_005564, 107 a.a. ~ 186 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4E4
Isotype IgG2a kappa
Specificity LMNB1 (NP_005564, 107 a.a. ~ 186 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name LMNB1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 66408 DA
Gene ID 12406
UniProt NP_005564
Research Area Cell Structure, Signaling, Chromatin
Application Notes Western blot = 1:500-1000
Comment

Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Lamin B1 (LMNB1) (AA 107-186) antibody LMNB1 monoclonal antibody (M03), clone 4E4. Western Blot analysis of LMNB1 expression in Jurkat.
Background publications Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Brussino, Vaula, Cagnoli et al.: "A family with autosomal dominant leukodystrophy linked to 5q23.2-q23.3 without lamin B1 mutations." in: European journal of neurology : the official journal of the European Federation of Neurological Societies, Vol. 17, Issue 4, pp. 541-9, 2010 (PubMed).

Kapinos, Schumacher, Mücke et al.: "Characterization of the head-to-tail overlap complexes formed by human lamin A, B1 and B2 "half-minilamin" dimers." in: Journal of molecular biology, Vol. 396, Issue 3, pp. 719-31, 2010 (PubMed).

Abramson, Giraud, Benoist et al.: "Aire's partners in the molecular control of immunological tolerance." in: Cell, Vol. 140, Issue 1, pp. 123-35, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
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