TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, C, 110kDa (TAF1C) antibody

Details for Product No. ABIN393929
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Synonyms SL1, TAFI95, TAFI110, MGC:39976, TAF1C
(11), (3), (1), (1), (1)
(10), (2)
Clonality (Clone)
Monoclonal ()
Western Blotting (WB)
(11), (3), (2), (1)
Pubmed 5 references available
Catalog no. ABIN393929
Quantity 0.1 mg
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Immunogen TAF1C (NP_005670, 761 a.a. ~ 870 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3E6
Isotype IgG2a kappa
Specificity TAF1C (NP_005670, 761 a.a. ~ 870 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TAF1C
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 95274 DA
Gene ID 12406
UniProt NP_005670
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000

Background: Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, C, 110kDa (TAF1C) antibody Western Blot analysis of TAF1C expression in transfected 293T cell line by TAF1C monoclonal antibody (M02), clone 3E6. Lane 1: TAF1C transfected lysate(85.1 KDa). Lane 2: Non-transfected lysate.
Background publications Friedrich, Panov, Cabart et al.: "TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter." in: The Journal of biological chemistry, Vol. 280, Issue 33, pp. 29551-8, 2005 (PubMed).

Zhang, Comai, Johnson: "PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex." in: Molecular and cellular biology, Vol. 25, Issue 16, pp. 6899-911, 2005 (PubMed).

Talmud, Drenos, Shah et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Anney, Klei, Pinto et al.: "A genome-wide scan for common alleles affecting risk for autism." in: Human molecular genetics, Vol. 19, Issue 20, pp. 4072-82, 2010 (PubMed).

Hosts (10), (2)
Reactivities (11), (3), (1), (1), (1)
Applications (11), (3), (2), (1)
Epitopes (4), (2), (2), (1)
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