Inhibitor of Growth Family, Member 3 (ING3) antibody

Details for Product No. ABIN393949
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Antigen
Synonyms Eaf4, ING2, MEAF4, p47ING3, zgc:56327, P47ING3, 1300013A07Rik, ING3
Reactivity
Human
(24), (9), (7), (6), (3), (2), (2), (2), (1)
Host
Mouse
(10), (10), (6)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
(23), (17), (7), (6), (4), (1)
Pubmed 5 references available
Catalog no. ABIN393949
Quantity 0.05 mg
Price
450.00 $   Plus shipping costs $45.00
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Immunogen ING3 (NP_938008, 1 a.a. ~ 93 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E9
Isotype IgG2a kappa
Specificity ING3 (NP_938008, 1 a.a. ~ 93 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name ING3
Background The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
Synonyms: Eaf4, FLJ20089, ING2, p47ING3 inhibitor of growth family, member 3
Molecular Weight 46743 DA
Gene ID 54556
UniProt NP_938008
Research Area Cancer, Signaling, Chromatin, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.

Restrictions For Research Use only
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Inhibitor of Growth Family, Member 3 (ING3) antibody ING3 monoclonal antibody (M01), clone 2E9. Western Blot analysis of ING3 expression in Hela NE.
Background publications Shi, Hong, Walter et al.: "ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression." in: Nature, Vol. 442, Issue 7098, pp. 96-9, 2006 (PubMed).

Wang, Dai, Martinka et al.: "Prognostic significance of nuclear ING3 expression in human cutaneous melanoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 14, pp. 4111-6, 2007 (PubMed).

Gunduz, Beder, Gunduz et al.: "Downregulation of ING3 mRNA expression predicts poor prognosis in head and neck cancer." in: Cancer science, Vol. 99, Issue 3, pp. 531-8, 2008 (PubMed).

Maestrini, Pagnamenta, Lamb et al.: "High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility." in: Molecular psychiatry, Vol. 15, Issue 9, pp. 954-68, 2010 (PubMed).

Chen, Wang, Garate et al.: "The tumor suppressor ING3 is degraded by SCF(Skp2)-mediated ubiquitin-proteasome system." in: Oncogene, Vol. 29, Issue 10, pp. 1498-508, 2010 (PubMed).

Hosts (10), (10), (6)
Reactivities (24), (9), (7), (6), (3), (2), (2), (2), (1)
Applications (23), (17), (7), (6), (4), (1)
Epitopes (5), (5), (2), (2), (1), (1)
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