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Details for Product No. ABIN393961

Inhibitor of DNA Binding 3, Dominant Negative Helix-Loop-Helix Protein (ID3) antibody

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Synonyms HEIR-1, bHLHb25, Idb3, Hlh462, ID3, MOR136-6, fa56g03, tdsubc_2g3, wu:fa56g03, ik:tdsubc_2g3, xx:tdsubc_2g3, heir-1, xid3, xidia
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN393961
Quantity 0.1 mg
450.00 $   Plus shipping costs $45.00
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Immunogen ID3 (NP_002158, 1 a.a. ~ 84 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3E10
Isotype IgG Mix kappa
Specificity ID3 (NP_002158, 1 a.a. ~ 84 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ID3
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 12969 DA
Gene ID 12406
UniProt NP_002158
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence

Background: Members of the ID family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers that are incapable of binding to DNA.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Trabosh, Daher, Divito et al.: "UVB upregulates the bax promoter in immortalized human keratinocytes via ROS induction of Id3." in: Experimental dermatology, Vol. 18, Issue 4, pp. 387-95, 2009 (PubMed).

Higgins, Wong, Richner et al.: "Fibroblast growth factor 2 reactivates G1 checkpoint in SK-N-MC cells via regulation of p21, inhibitor of differentiation genes (Id1-3), and epithelium-mesenchyme transition-like events." in: Endocrinology, Vol. 150, Issue 9, pp. 4044-55, 2009 (PubMed).

Shuno, Tsuno, Okaji et al.: "Id1/Id3 knockdown inhibits metastatic potential of pancreatic cancer." in: The Journal of surgical research, Vol. 161, Issue 1, pp. 76-82, 2010 (PubMed).

McGeachie, Ramoni, Mychaleckyj et al.: "Integrative predictive model of coronary artery calcification in atherosclerosis." in: Circulation, Vol. 120, Issue 24, pp. 2448-54, 2009 (PubMed).

Doran, Lehtinen, Meller et al.: "Id3 is a novel atheroprotective factor containing a functionally significant single-nucleotide polymorphism associated with intima-media thickness in humans." in: Circulation research, Vol. 106, Issue 7, pp. 1303-11, 2010 (PubMed).

Alternatives for antigen "Inhibitor of DNA Binding 3, Dominant Negative Helix-Loop-Helix Protein (ID3)", type "Antibodies"
Hosts (37), (27)
Reactivities (60), (20), (15), (13), (13), (13)
Applications (35), (22), (15), (14), (10), (7), (6), (1), (1), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (7), (7), (6), (2), (2), (1), (1), (1), (1)