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Vanin 1 (VNN1) (AA 298-398) antibody

Details for Product No. ABIN393972, Supplier: Log in to see
Antigen
  • hdlcq8
  • tiff66
  • vnn1.1
  • vanin-1
  • V-1
  • HDLCQ8
  • Tiff66
Epitope
AA 298-398
5
5
5
5
4
3
2
2
2
1
1
1
1
1
Reactivity
Human
43
15
8
2
1
1
Host
Mouse
44
9
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
4
4
1
Application
Immunofluorescence (IF), ELISA
30
26
8
5
5
4
4
2
1
1
1
Supplier
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Immunogen VNN1 (NP_004657, 298 a.a. ~ 398 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4E11
Isotype IgG2a kappa
Specificity VNN1 (NP_004657, 298 a.a. ~ 398 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name VNN1 (VNN1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 57012 DA
Gene ID 12406
NCBI Accession NP_004657
Research Area Cell Structure, Transcription Factors, Signaling
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Vanin 1 (VNN1) (AA 298-398) antibody (ABIN393972) VNN1 monoclonal antibody (M08), clone 4E11. Western Blot analysis of VNN1 expression ...
Background publications Lei, Papasian, Deng: "Polymorphisms in predicted miRNA binding sites and osteoporosis." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 26, Issue 1, pp. 72-8, 2010 (PubMed).

Huang, Dong, Kang et al.: "Novel blood biomarkers of pancreatic cancer-associated diabetes mellitus identified by peripheral blood-based gene expression profiles." in: The American journal of gastroenterology, Vol. 105, Issue 7, pp. 1661-9, 2010 (PubMed).

Jansen, Kamsteeg, Rodijk-Olthuis et al.: "Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines." in: The Journal of investigative dermatology, Vol. 129, Issue 9, pp. 2167-74, 2009 (PubMed).

Zhu, Cooper: "Admixture mapping provides evidence of association of the VNN1 gene with hypertension." in: PLoS ONE, Vol. 2, Issue 11, pp. e1244, 2007 (PubMed).

Min-Oo, Fortin, Pitari et al.: "Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus." in: The Journal of experimental medicine, Vol. 204, Issue 3, pp. 511-24, 2007 (PubMed).