ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) antibody

Details for Product No. ABIN393989
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Synonyms Berg36, Brf1, ERF1, TIS11b, cMG1, ZFP36L1, berg36, brf1, c3h-2, cmg1, erf-1, erf1, rnf162b, tis11b, BRF1, ERF-1, TIS11B, RNF162B, AW742437, AW743212, D530020L18Rik
(65), (45), (41), (39), (37), (28), (12), (1)
(59), (7)
Clonality (Clone)
Monoclonal ()
(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Western Blotting (WB)
(36), (30), (22), (10), (8), (5), (3), (2), (2)
Pubmed 5 references available
Catalog no. ABIN393989
Quantity 0.1 mg
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Immunogen ZFP36L1 (NP_004917, 1 a.a. ~ 109 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1A3
Isotype IgG1 kappa
Specificity ZFP36L1 (NP_004917, 1 a.a. ~ 109 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ZFP36L1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 36314 DA
Gene ID 12406
UniProt NP_004917
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000

Background: This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) antibody Western blot analysis of ZFP36L1 over-expressed 293 cell line, cotransfected with ZFP36L1 Validated Chimera RNAi used as specificity and loading control. Western Blot analysis of ZFP36L1 expression in transfected 293T cell line by ZFP36L1 monoclonal antibody (M02), clone 1A3. Lane 1: ZFP36L1 transfected lysate(36.3 KDa). Lane 2: Non-transfected lysate.
anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) antibody (2) anti-ZFP36 Ring Finger Protein-Like 1 (ZFP36L1) antibody (Image 2)
Background publications Baou, Jewell, Muthurania et al.: "Involvement of Tis11b, an AU-rich binding protein, in induction of apoptosis by rituximab in B cell chronic lymphocytic leukemia cells." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 23, Issue 5, pp. 986-9, 2009 (PubMed).

Cheng, Saito, Pisarev et al.: "Structural insights into eRF3 and stop codon recognition by eRF1." in: Genes & development, Vol. 23, Issue 9, pp. 1106-18, 2009 (PubMed).

Sinha, Dutta, Datta et al.: "Von Hippel-Lindau gene product modulates TIS11B expression in renal cell carcinoma: impact on vascular endothelial growth factor expression in hypoxia." in: The Journal of biological chemistry, Vol. 284, Issue 47, pp. 32610-8, 2009 (PubMed).

Hacker, Valchanova, Adams et al.: "ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production." in: Growth factors (Chur, Switzerland), Vol. 28, Issue 3, pp. 178-90, 2010 (PubMed).

Dubois, Trynka, Franke et al.: "Multiple common variants for celiac disease influencing immune gene expression...." in: Nature genetics, Vol. 42, Issue 4, pp. 295-302, 2010 (PubMed).

Hosts (59), (7)
Reactivities (65), (45), (41), (39), (37), (28), (12), (1)
Applications (36), (30), (22), (10), (8), (5), (3), (2), (2)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (13), (13), (12), (3), (2), (2), (1), (1), (1), (1)
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