T-Complex Protein 1 Subunit zeta-2-Like (CCT6B) (AA 1-531) antibody

Details for Product No. ABIN393990
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Antigen
Synonyms CCT-zeta-2, CCTZ-2, Cctz2, TCP-1-zeta-2, TSA303, CCTzeta-2, Cctz-2
Epitope
AA 1-531
(5), (3), (2)
Reactivity
Human
(15), (3), (3), (1), (1), (1)
Host
Mouse
(12), (3)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
(13), (6), (4), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393990
450.00 $
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Immunogen CCT6B (AAH27591, 1 a.a. ~ 531 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1A4
Isotype IgG2a kappa
Specificity CCT6B (AAH27591, 1 a.a. ~ 531 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CCT6B
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 57765 DA
Gene ID 12406
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-T-Complex Protein 1 Subunit zeta-2-Like (CCT6B) (AA 1-531) antibody Western Blot analysis of CCT6B expression in transfected 293T cell line by CCT6B monoclonal antibody (M01), clone 1A4. Lane 1: CCT6B transfected lysate(57.8 KDa). Lane 2: Non-transfected lysate. CCT6B monoclonal antibody (M01), clone 1A4 Western Blot analysis of CCT6B expression in HL-60.
anti-T-Complex Protein 1 Subunit zeta-2-Like (CCT6B) (AA 1-531) antibody (2) anti-T-Complex Protein 1 Subunit zeta-2-Like (CCT6B) (AA 1-531) antibody (Image 2)
Background publications Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Talmud, Drenos, Shah et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Stirling, Cuéllar, Alfaro et al.: "PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates." in: The Journal of biological chemistry, Vol. 281, Issue 11, pp. 7012-21, 2006 (PubMed).

Goudreault, DAmbrosio, Kean et al.: "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein." in: Molecular & cellular proteomics : MCP, Vol. 8, Issue 1, pp. 157-71, 2009 (PubMed).

Mukherjee, Conway de Macario, Macario et al.: "Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes." in: BMC evolutionary biology, Vol. 10, pp. 64, 2010 (PubMed).

Validation Images
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