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FOXA1 antibody (Forkhead Box A1) (AA 367-473)

Details for Product anti-FOXA1 Antibody No. ABIN393996, Supplier: Log in to see
Antigen
  • Ci-fkh
  • fkd7
  • fkh
  • fkh1
  • fkh2
  • forkhead-7
  • Foxa1
  • foxa1
  • FOXA1
  • foxa3
  • FoxA4a
  • HNF-3a
  • Hnf-3a
  • HNF3-alpha
  • HNF3A
  • Hnf3a
  • hnf3a
  • HNF3alpha
  • pintallavis
  • Tcf-3a
  • TCF3A
  • tcf3a
  • Tcf3a
  • tFoxA1
  • XFD-1
  • xfkh1
  • xfkh2
  • xkfh-1
Epitope
AA 367-473
33
18
16
16
14
13
9
7
6
5
4
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
195
34
31
7
6
5
3
2
1
1
1
Host
Mouse
101
74
20
Clonality (Clone)
Monoclonal ()
Conjugate
This FOXA1 antibody is un-conjugated
6
6
5
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
163
93
82
77
71
50
47
11
9
9
6
2
1
1
1
Supplier
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Supplier Product No.
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Immunogen FOXA1 (NP_004487, 367 a.a. ~ 473 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1B1
Isotype IgG2a kappa
Specificity FOXA1 (NP_004487, 367 a.a. ~ 473 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FOXA1 (FOXA1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 49321 DA
Gene ID 12406
NCBI Accession NP_004487
Research Area Transcription Factors, Signaling, Chromatin, Metabolism, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-FOXA1 antibody (Forkhead Box A1) (AA 367-473) (ABIN393996) Immunofluorescence of monoclonal antibody to FOXA1 on HepG2 cell (antibody concentrat...
Immunohistochemistry (IHC) image for anti-FOXA1 antibody (Forkhead Box A1) (AA 367-473) (ABIN393996) anti-Forkhead Box A1 (FOXA1) (AA 367-473) antibody (Image 2)
Background publications Liu, Niu, Wang, Yu, Zhang, Liu: "[Diagnostic and prognostic significance of FOXA1 expression in molecular subtypes of breast invasive ductal carcinomas]." in: Zhonghua yi xue za zhi, Vol. 90, Issue 20, pp. 1403-7, 2010 (PubMed).

Bernardo, Lozada, Miedler, Harburg, Hewitt, Mosley, Godwin, Korach, Visvader, Kaestner, Abdul-Karim, Montano, Keri: "FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis." in: Development (Cambridge, England), Vol. 137, Issue 12, pp. 2045-54, 2010 (PubMed).

Song, Washington, Crawford: "Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer." in: Cancer research, Vol. 70, Issue 5, pp. 2115-25, 2010 (PubMed).

Zhang, Ali, Zhou, DSouza, Lu, Jaffe, Liu, Passaniti, Hamburger: "ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer." in: Cancer research, Vol. 70, Issue 1, pp. 240-8, 2010 (PubMed).

Sano, Aoyagi, Takahashi, Kawamura, Mabuchi, Igaki, Tachimori, Kato, Ochiai, Honda, Nimura, Nagino, Yoshida, Sasaki: "Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamous cell carcinomas with extensive lymph node metastasis." in: International journal of oncology, Vol. 36, Issue 2, pp. 321-30, 2009 (PubMed).