Forkhead Box A1 (FOXA1) antibody

Antigen: Forkhead Box A1 (FOXA1)

Synonyms: HNF3A, TCF3A, MGC33105, Hnf3a, Tcf3a, Hnf-3a, Tcf-3a, fkd7, forkhead-7, foxa1, MGC52590, xfkh1, FoxA4a, MGC75967, pintallavis, tcf3a, xfkh2, tFoxA1, HNF3alpha, HNF3-alpha, fkh, FOXA1, Ci-fkh, HNF-3a, foxa3, Foxa1

Clonality: Monoclonal (1B1)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393996

Additional Information

Alternative name: FOXA1

Gene ID: 3169

UniProt: NP_004487

Immunogen: FOXA1 (NP_004487, 367 a.a. ~ 473 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 1B1

Description: Other names: HNF3A, MGC33105, TCF3A forkhead box A1

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: FOXA1 (NP_004487, 367 a.a. ~ 473 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 49321 DA

Comments:

Background: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.

Synonyms: HNF3A, TCF3A, MGC33105, Hnf3a, Tcf3a, Hnf-3a, Tcf-3a, fkd7, forkhead-7, foxa1, MGC52590, xfkh1, FoxA4a, MGC75967, pintallavis, tcf3a, xfkh2, tFoxA1, HNF3alpha, HNF3-alpha, fkh, FOXA1, Ci-fkh, HNF-3a, foxa3, Foxa1

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml Immunofluorescence

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Transcription Factors, Signaling, Chromatin, Metabolism, Cell Structure

Restrictions: For Research Use only

Images

Immunofluorescence of monoclonal antibody to FOXA1 (AT2082a) on HepG2 cell . [antibody concentration 10 ug/ml] FOXA1 monoclonal antibody (M02), clone 1B1 Western Blot analysis of FOXA1 expression in HepG2 ( Cat # L019V1 ).

anti-Forkhead Box A1 (FOXA1) antibody (Image 2)

Publications

Product: Sano, Aoyagi, Takahashi et al.: "Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamous cell carcinomas with extensive lymph node metastasis." in: International journal of oncology, Vol. 36, Issue 2, pp. 321-30, 2009 (PubMed).

Zhang, Ali, Zhou et al.: "ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer." in: Cancer research, Vol. 70, Issue 1, pp. 240-8, 2010 (PubMed).

Song, Washington, Crawford: "Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer." in: Cancer research, Vol. 70, Issue 5, pp. 2115-25, 2010 (PubMed).

Bernardo, Lozada, Miedler et al.: "FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis." in: Development (Cambridge, England), Vol. 137, Issue 12, pp. 2045-54, 2010 (PubMed).

Liu, Niu, Wang et al.: "[Diagnostic and prognostic significance of FOXA1 expression in molecular subtypes of breast invasive ductal carcinomas]." in: Zhonghua yi xue za zhi, Vol. 90, Issue 20, pp. 1403-7, 2010 (PubMed).