BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) (AA 396-493) antibody

Details for Product No. ABIN394012
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Antigen
Synonyms zgc:112205, BACH1, 6230421P05Rik, AI323795, BACH-1
Epitope
AA 396-493
(11), (8), (6), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(56), (8), (5), (2)
Host
Mouse
(42), (9), (5), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(55), (30), (10), (7), (5), (2), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394012
450.00 $
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Immunogen BACH1 (NP_996749, 396 a.a. ~ 493 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1B8
Isotype IgG2a kappa
Specificity BACH1 (NP_996749, 396 a.a. ~ 493 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BACH1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 81958 DA
Gene ID 12406
NCBI Accession NP_996749
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) (AA 396-493) antibody BACH1 monoclonal antibody (M02), clone 1B8 Western Blot analysis of BACH1 expression in NIH/3T3. Detection limit for recombinant GST tagged BACH1 is approximately 0.03 ng/mL as a capture antibody.
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) (AA 396-493) antibody (2) anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) (AA 396-493) antibody (Image 2)
Background publications Goven, Boutten, Leçon-Malas et al.: "Prolonged cigarette smoke exposure decreases heme oxygenase-1 and alters Nrf2 and Bach1 expression in human macrophages: roles of the MAP kinases ERK(1/2) and JNK." in: FEBS letters, Vol. 583, Issue 21, pp. 3508-18, 2009 (PubMed).

Zhong, Raval, Edwards et al.: "A role for Bach1 and HO-2 in suppression of basal and UVA-induced HO-1 expression in human keratinocytes." in: Free radical biology & medicine, Vol. 48, Issue 2, pp. 196-206, 2010 (PubMed).

Hou, Tian, Zheng et al.: "MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins." in: Hepatology (Baltimore, Md.), Vol. 51, Issue 5, pp. 1494-504, 2010 (PubMed).

Gong, Kim, Leung et al.: "BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control." in: Molecular cell, Vol. 37, Issue 3, pp. 438-46, 2010 (PubMed).

Miyazaki, Kirino, Takeno et al.: "Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1." in: Cancer science, Vol. 101, Issue 6, pp. 1409-16, 2010 (PubMed).

Validation Images
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