BACH1 antibody (BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1) (AA 396-493)

Details for Product anti-BACH1 Antibody No. ABIN394012, Supplier: Log in to see
Antigen
  • zgc:112205
  • BACH1
  • 6230421P05Rik
  • AI323795
  • BACH-1
  • BTB and CNC homology 1, basic leucine zipper transcription factor 1
  • BTB and CNC homology 1
  • BACH1
  • bach1
  • Bach1
Epitope
AA 396-493
14
9
9
9
7
6
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
99
12
9
5
1
1
Host
Mouse
71
15
13
1
Clonality (Clone)
Monoclonal ()
Conjugate
This BACH1 antibody is un-conjugated
4
3
3
3
3
3
Application
Western Blotting (WB)
92
49
16
16
15
7
3
3
3
2
2
1
Options
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Immunogen BACH1 (NP_996749, 396 a.a. ~ 493 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1B8
Isotype IgG2a kappa
Specificity BACH1 (NP_996749, 396 a.a. ~ 493 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BACH1 (BACH1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 81958 DA
Gene ID 12406
NCBI Accession NP_996749
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-BACH1 antibody (BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1) (AA 396-493) (ABIN394012) BACH1 monoclonal antibody (M02), clone 1B8 Western Blot analysis of BACH1 expression ...
Immunohistochemistry (IHC) image for anti-BACH1 antibody (BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1) (AA 396-493) (ABIN394012) anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) (AA 396-493) antibody (Image 2)
Background publications Miyazaki, Kirino, Takeno, Samukawa, Hama, Tanaka, Yamaji, Ueda, Tomita, Fujita, Ishigatsubo: "Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1." in: Cancer science, Vol. 101, Issue 6, pp. 1409-16, 2010 (PubMed).

Gong, Kim, Leung, Glover, Chen: "BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control." in: Molecular cell, Vol. 37, Issue 3, pp. 438-46, 2010 (PubMed).

Hou, Tian, Zheng, Bonkovsky: "MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins." in: Hepatology (Baltimore, Md.), Vol. 51, Issue 5, pp. 1494-504, 2010 (PubMed).

Zhong, Raval, Edwards, Tyrrell: "A role for Bach1 and HO-2 in suppression of basal and UVA-induced HO-1 expression in human keratinocytes." in: Free radical biology & medicine, Vol. 48, Issue 2, pp. 196-206, 2010 (PubMed).

Goven, Boutten, Leçon-Malas, Boczkowski, Bonay: "Prolonged cigarette smoke exposure decreases heme oxygenase-1 and alters Nrf2 and Bach1 expression in human macrophages: roles of the MAP kinases ERK(1/2) and JNK." in: FEBS letters, Vol. 583, Issue 21, pp. 3508-18, 2009 (PubMed).