Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN394022

Forkhead Box A2 (FOXA2) (Met10) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms
HNF3B, TCF3B, Hnf3b, Tcf3b, Hnf-3b, Tcf-3b, HNF3beta, HNF3-beta, HNF-3B, ax, axl, fkd1, ik:tdsubc_2g8, tdsubc_2g8, wu:fe05g04, xx:tdsubc_2g8, HNF-3BETA, HNF-3b, hnf3b, xFD-3, FoxA2a, FoxA2-A, xbeta-1, ... show more
Epitope
»Alternatives Met10
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN394022
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 2 to 3 Business Days
Immunogen FOXA2 (NP_068556, 363 a.a. ~ 458 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1C7
Isotype IgG2a kappa
Specificity FOXA2 (NP_068556, 363 a.a. ~ 458 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FOXA2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 48306 DA
Gene ID 12406
UniProt NP_068556
Research Area Transcription Factors, Signaling, Chromatin, Metabolism, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml Immunofluorescence
Comment

Background: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Xing, Cohen, Boerwinkle: "A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels." in: American journal of human genetics, Vol. 86, Issue 3, pp. 440-6, 2010 (PubMed).

Song, Washington, Crawford: "Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer." in: Cancer research, Vol. 70, Issue 5, pp. 2115-25, 2010 (PubMed).

Banerjee, Meyer, Mazumdar et al.: "Hepatitis C virus differentially modulates activation of forkhead transcription factors and insulin-induced metabolic gene expression." in: Journal of virology, Vol. 84, Issue 12, pp. 5936-46, 2010 (PubMed).

Dayoub, Groitl, Dobner et al.: "Foxa2 (HNF-3beta) regulates expression of hepatotrophic factor ALR in liver cells." in: Biochemical and biophysical research communications, Vol. 395, Issue 4, pp. 465-70, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Alternatives for antigen "Forkhead Box A2 (FOXA2)", type "Antibodies"
Hosts (38), (37), (12)
Reactivities (82), (22), (19), (13), (12), (12), (3), (1), (1)
Applications (77), (49), (25), (22), (19), (10), (5), (3), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (12), (5), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Beacon