NK3 Homeobox 1 (NKX3-1) (AA 100-210) antibody

Details for Product No. ABIN394023
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Antigen
Synonyms Xbagpipe, Xbap, bagpipe, koza, nkx3-1, nkx3.1, si:ch211-67o1.2, nkx3a, MGC53041, MGC97890, Bax, NKX3.1, NKX3A, Nkx-3.1, BAPX2, NKX3
Epitope
AA 100-210
(16), (12), (11), (7), (7), (5), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(87), (20), (7), (1), (1), (1)
Host
Mouse
(65), (35), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (4), (4), (4), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(79), (50), (30), (14), (12), (4), (2), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394023
450.00 $
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Immunogen NKX3-1 (NP_006158, 100 a.a. ~ 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1C7
Isotype IgG2a kappa
Specificity NKX3-1 (NP_006158, 100 a.a. ~ 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name NKX3-1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 26350 DA
Gene ID 12406
NCBI Accession NP_006158
Research Area Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-NK3 Homeobox 1 (NKX3-1) (AA 100-210) antibody Immunofluorescence of monoclonal antibody to NKX3-1 on NIH/3T3 cell (antibody concentration 10 µg/mL). NKX3-1 monoclonal antibody (M02), clone 1C7 Western Blot analysis of NKX3-1 expression in NIH/3T3.
anti-NK3 Homeobox 1 (NKX3-1) (AA 100-210) antibody (2) anti-NK3 Homeobox 1 (NKX3-1) (AA 100-210) antibody (Image 2)
Background publications Thomas, Preece, Bentel: "Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3' untranslated region." in: The Biochemical journal, Vol. 425, Issue 3, pp. 575-83, 2010 (PubMed).

Bowen, Gelmann: "NKX3.1 activates cellular response to DNA damage." in: Cancer research, Vol. 70, Issue 8, pp. 3089-97, 2010 (PubMed).

Kunderfranco, Mello-Grand, Cangemi et al.: "ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer." in: PLoS ONE, Vol. 5, Issue 5, pp. e10547, 2010 (PubMed).

Kim, Cheng, Hsu et al.: "Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation." in: The Prostate, Vol. 70, Issue 16, pp. 1729-38, 2010 (PubMed).

Gurel, Ali, Montgomery et al.: "NKX3.1 as a marker of prostatic origin in metastatic tumors." in: The American journal of surgical pathology, Vol. 34, Issue 8, pp. 1097-105, 2010 (PubMed).

Validation Images
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