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AEBP1 antibody (AE Binding Protein 1) (AA 912-1014)

Details for Product anti-AEBP1 Antibody No. ABIN394034, Supplier: Log in to see
Antigen
  • ACLP
Epitope
AA 912-1014
15
13
9
4
2
2
1
1
Reactivity
Human
28
7
4
2
1
Host
Mouse
23
5
Clonality (Clone)
Monoclonal ()
Conjugate
This AEBP1 antibody is un-conjugated
2
2
2
2
2
2
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
27
22
6
2
1
1
1
Supplier
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Immunogen AEBP1 (NP_001120, 912 a.a. ~ 1014 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1D2
Isotype IgG2a kappa
Specificity AEBP1 (NP_001120, 912 a.a. ~ 1014 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name AEBP1 (AEBP1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 130929 DA
Gene ID 12406
NCBI Accession NP_001120
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml
Comment

Background: The adipocyte enhancer binding protein 1 is a transcriptional repressor with carboxypeptidase (CP) activity. This protein binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of the regulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding of DNA enhances its protease activity. Adipocyte-enhancer binding protein 1 may play a role in differentiated vascular smooth muscle cells.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-AEBP1 antibody (AE Binding Protein 1) (AA 912-1014) (ABIN394034) Immunoperoxidase of monoclonal antibody to AEBP1 on formalin-fixed paraffin-embedded ...
Immunohistochemistry (IHC) image for anti-AEBP1 antibody (AE Binding Protein 1) (AA 912-1014) (ABIN394034) anti-AE Binding Protein 1 (AEBP1) (AA 912-1014) antibody (Image 2)
Background publications Majdalawieh, Ro: "PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1." in: Nuclear receptor signaling, Vol. 8, pp. e004, 2010 (PubMed).

Schissel, Dunsmore, Liu et al.: "Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis." in: The American journal of pathology, Vol. 174, Issue 3, pp. 818-28, 2009 (PubMed).

Zhang, Reidy, Nicholson et al.: "The role of AEBP1 in sex-specific diet-induced obesity." in: Molecular medicine (Cambridge, Mass.), Vol. 11, Issue 1-12, pp. 39-47, 2006 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Scherer, Cheung, MacDonald et al.: "Human chromosome 7: DNA sequence and biology. ..." in: Science (New York, N.Y.), Vol. 300, Issue 5620, pp. 767-72, 2003 (PubMed).