AE Binding Protein 1 (AEBP1) (AA 912-1014) antibody

Details for Product No. ABIN394034
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms ACLP
Epitope
AA 912-1014
(8), (6), (4), (2), (2), (1), (1), (1)
Reactivity
Human
(31), (18), (15), (2), (1)
Host
Mouse
(27), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(22), (13), (10), (6), (4)
Pubmed 5 references available
Quantity 0.1 mg
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN394034
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen AEBP1 (NP_001120, 912 a.a. ~ 1014 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1D2
Isotype IgG2a kappa
Specificity AEBP1 (NP_001120, 912 a.a. ~ 1014 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name AEBP1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 130929 DA
Gene ID 12406
NCBI Accession NP_001120
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml
Comment

Background: The adipocyte enhancer binding protein 1 is a transcriptional repressor with carboxypeptidase (CP) activity. This protein binds to a regulatory sequence, adipocyte enhancer 1 (AE-1), located in the proximal promoter region of the adipose P2 (aP2) gene, which encodes the adipocyte fatty-acid binding protein. It is characterized as a member of the regulatory B-like CP family. This protein seems to be activated by a novel mechanism, whereby the direct binding of DNA enhances its protease activity. Adipocyte-enhancer binding protein 1 may play a role in differentiated vascular smooth muscle cells.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-AE Binding Protein 1 (AEBP1) (AA 912-1014) antibody Immunoperoxidase of monoclonal antibody to AEBP1 on formalin-fixed paraffin-embedded human adrenal gland (antibody concentration 3 µg/mL). Detection limit for recombinant GST tagged AEBP1 is approximately 0.3 ng/mL as a capture antibody.
anti-AE Binding Protein 1 (AEBP1) (AA 912-1014) antibody (2) anti-AE Binding Protein 1 (AEBP1) (AA 912-1014) antibody (Image 2)
Background publications Scherer, Cheung, MacDonald et al.: "Human chromosome 7: DNA sequence and biology." in: Science (New York, N.Y.), Vol. 300, Issue 5620, pp. 767-72, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Zhang, Reidy, Nicholson et al.: "The role of AEBP1 in sex-specific diet-induced obesity." in: Molecular medicine (Cambridge, Mass.), Vol. 11, Issue 1-12, pp. 39-47, 2006 (PubMed).

Schissel, Dunsmore, Liu et al.: "Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis." in: The American journal of pathology, Vol. 174, Issue 3, pp. 818-28, 2009 (PubMed).

Majdalawieh, Ro: "PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1." in: Nuclear receptor signaling, Vol. 8, pp. e004, 2010 (PubMed).

Validation Images
Did you look for something else?
back to top