Nuclear Transcription Factor Y, gamma (NFYC) (AA 14-113) antibody

Details for Product No. ABIN394039
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Antigen
Synonyms cbf-c, cbfc, h1tf2a, hap5, hsm, nf-yc, NFYC, Nfyc, CBF-C, CBFC, H1TF2A, HAP5, HSM, NF-YC, fb98f01, wu:fb98f01, zgc:55514
Epitope
AA 14-113
(9), (8), (7), (5), (1), (1), (1), (1), (1)
Reactivity
Human
(38), (12), (12), (3), (3), (2), (1), (1)
Host
Mouse
(30), (8)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(37), (24), (11), (5), (3), (2), (2), (1), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN394039
450.00 $
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Immunogen NFYC (AAH05003, 14 a.a. ~ 113 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1D3
Isotype IgG3 kappa
Specificity NFYC (AAH05003, 14 a.a. ~ 113 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name NFYC
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 50302 DA
Gene ID 12406
Research Area Transcription Factors, Signaling, Chromatin, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Nuclear Transcription Factor Y, gamma (NFYC) (AA 14-113) antibody Western blot analysis of NFYC over-expressed 293 cell line, cotransfected with NFYC Validated Chimera RNAi used as specificity and loading control. Western Blot analysis of NFYC expression in transfected 293T cell line by NFYC monoclonal antibody (M01), clone 1D3. Lane 1: NFYC transfected lysate(37.2 KDa). Lane 2: Non-transfected lysate.
anti-Nuclear Transcription Factor Y, gamma (NFYC) (AA 14-113) antibody (2) anti-Nuclear Transcription Factor Y, gamma (NFYC) (AA 14-113) antibody (Image 2)
Background publications Horikawa, Wood, Yang et al.: "Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 23, pp. 7956-62, 2008 (PubMed).

Yamanaka, Mizuarai, Eguchi et al.: "Expression levels of NF-Y target genes changed by CDKN1B correlate with clinical prognosis in multiple cancers." in: Genomics, Vol. 94, Issue 4, pp. 219-27, 2009 (PubMed).

Ceribelli, Benatti, Imbriano et al.: "NF-YC complexity is generated by dual promoters and alternative splicing." in: The Journal of biological chemistry, Vol. 284, Issue 49, pp. 34189-200, 2009 (PubMed).

Murai-Takeda, Shibata, Kurihara et al.: "NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor." in: The Journal of biological chemistry, Vol. 285, Issue 11, pp. 8084-93, 2010 (PubMed).

Ichikawa, Koller, Padgett et al.: "Replication of previous genome-wide association studies of bone mineral density in premenopausal American women." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 25, Issue 8, pp. 1821-9, 2010 (PubMed).

Validation Images
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