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IKZF3 antibody (IKAROS Family Zinc Finger 3 (Aiolos)) (AA 1-510)

Details for Product anti-IKZF3 Antibody No. ABIN394045, Supplier: Log in to see
Antigen
  • 5830411O07Rik
  • aio
  • AIO
  • Aiolos
  • aiolos
  • AIOLOS
  • Zfpn1a3
  • znfn1a3
  • ZNFN1A3
  • Znfn1a3
Epitope
AA 1-510
16
15
14
11
9
6
5
5
5
4
3
2
1
1
1
1
Reactivity
Human
116
45
25
8
4
4
4
2
2
2
1
1
1
Host
Mouse
77
52
Clonality (Clone)
Monoclonal ()
Conjugate
This IKZF3 antibody is un-conjugated
7
4
4
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF)
83
51
17
16
13
13
11
11
7
2
1
1
Supplier
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Supplier Product No.
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Immunogen ZNFN1A3 (AAH32707, 1 a.a. ~ 510 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1D7
Isotype IgG2b kappa
Specificity ZNFN1A3 (AAH32707, 1 a.a. ~ 510 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ZNFN1A3 (IKZF3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 57943 DA
Gene ID 12406
Research Area Cell Cycle, Transcription Factors, Signaling, Chromatin, Cell Structure
Comment

Background: This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Immunofluorescence (IF) image for anti-IKZF3 antibody (IKAROS Family Zinc Finger 3 (Aiolos)) (AA 1-510) (ABIN394045) Immunofluorescence of to ZNFN1A3 on HeLa cell . Detection limit for recombinant GST t...
Immunohistochemistry (IHC) image for anti-IKZF3 antibody (IKAROS Family Zinc Finger 3 (Aiolos)) (AA 1-510) (ABIN394045) anti-IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) (AA 1-510) antibody (Image 2)
Background publications Matulić, Paradzik, Puskarić, Stipić, Antica: "Analysis of Ikaros family splicing variants in human hematopoietic lineages." in: Collegium antropologicum, Vol. 34, Issue 1, pp. 59-62, 2010

Billot, Parizot, Arrouss, Mazier, Debre, Rogner, Rebollo: "Differential aiolos expression in human hematopoietic subpopulations." in: Leukemia research, Vol. 34, Issue 3, pp. 289-93, 2010

Hirschfield, Liu, Xu, Lu, Xie, Lu, Gu, Walker, Jing, Juran, Mason, Myers, Peltekian, Ghent, Coltescu, Atkinson, Heathcote, Lazaridis, Amos, Siminovitch: "Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants." in: The New England journal of medicine, Vol. 360, Issue 24, pp. 2544-55, 2009

Mavaddat, Dunning, Ponder, Easton, Pharoah: "Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 1, pp. 255-9, 2009

Vieira, McHenry, Daack-Hirsch, Murray, Marazita: "Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 10, Issue 9, pp. 668-74, 2008