IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) (AA 1-510) antibody

Details for Product No. ABIN394045
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Antigen
Synonyms 5830411O07Rik, Aiolos, Zfpn1a3, Znfn1a3, AIO, AIOLOS, ZNFN1A3, aio, aiolos, znfn1a3
Epitope
AA 1-510
(9), (7), (7), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(54), (27), (18), (16), (14), (14), (12), (2), (1), (1), (1)
Host
Mouse
(43), (11)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF)
(43), (25), (10), (8), (7), (2), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394045
450.00 $
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Immunogen ZNFN1A3 (AAH32707, 1 a.a. ~ 510 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1D7
Isotype IgG2b kappa
Specificity ZNFN1A3 (AAH32707, 1 a.a. ~ 510 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ZNFN1A3
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 57943 DA
Gene ID 12406
Research Area Cell Cycle, Transcription Factors, Signaling, Chromatin, Cell Structure
Comment

Background: This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) (AA 1-510) antibody Immunofluorescence of to ZNFN1A3 on HeLa cell . Detection limit for recombinant GST tagged ZNFN1A3 is approximately 10 ng/mL as a capture antibody.
anti-IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) (AA 1-510) antibody (2) anti-IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) (AA 1-510) antibody (Image 2)
Background publications Vieira, McHenry, Daack-Hirsch et al.: "Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 10, Issue 9, pp. 668-74, 2008 (PubMed).

Mavaddat, Dunning, Ponder et al.: "Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 1, pp. 255-9, 2009 (PubMed).

Hirschfield, Liu, Xu et al.: "Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants." in: The New England journal of medicine, Vol. 360, Issue 24, pp. 2544-55, 2009 (PubMed).

Billot, Parizot, Arrouss et al.: "Differential aiolos expression in human hematopoietic subpopulations." in: Leukemia research, Vol. 34, Issue 3, pp. 289-93, 2010 (PubMed).

Matulić, Paradzik, Puskarić et al.: "Analysis of Ikaros family splicing variants in human hematopoietic lineages." in: Collegium antropologicum, Vol. 34, Issue 1, pp. 59-62, 2010 (PubMed).

Validation Images
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