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Details for Product No. ABIN394045

IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3) antibody

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Antigen
Synonyms AIO, AIOLOS, ZNFN1A3, 5830411O07Rik, Aiolos, Zfpn1a3, Znfn1a3, aio, aiolos, znfn1a3
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN394045
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Immunogen ZNFN1A3 (AAH32707, 1 a.a. ~ 510 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1D7
Isotype IgG2b kappa
Specificity ZNFN1A3 (AAH32707, 1 a.a. ~ 510 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ZNFN1A3
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 57943 DA
Gene ID 12406
Research Area Cell Cycle, Transcription Factors, Signaling, Chromatin, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence
Comment

Background: This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Vieira, McHenry, Daack-Hirsch et al.: "Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 10, Issue 9, pp. 668-74, 2008 (PubMed).

Mavaddat, Dunning, Ponder et al.: "Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 1, pp. 255-9, 2009 (PubMed).

Hirschfield, Liu, Xu et al.: "Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants." in: The New England journal of medicine, Vol. 360, Issue 24, pp. 2544-55, 2009 (PubMed).

Billot, Parizot, Arrouss et al.: "Differential aiolos expression in human hematopoietic subpopulations." in: Leukemia research, Vol. 34, Issue 3, pp. 289-93, 2010 (PubMed).

Matulić, Paradzik, Puskarić et al.: "Analysis of Ikaros family splicing variants in human hematopoietic lineages." in: Collegium antropologicum, Vol. 34, Issue 1, pp. 59-62, 2010 (PubMed).

Alternatives for antigen "IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3)", type "Antibodies"
Hosts (35), (5)
Reactivities (41), (24), (16), (14), (13), (13), (12), (2), (1), (1)
Applications (29), (15), (10), (8), (2), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1)
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