Hepatocyte Nuclear Factor 4, alpha (HNF4A) (AA 324-424) antibody

Details for Product No. ABIN394055
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Antigen
Synonyms
HNF4A, HNF4alpha, CG9310, DmHNF4, Dmel\\CG9310, HNF-4, HNF-4(D), HNF4, Hnf-4, Hnf-4h, NR2A4, dHNF-4, dHNF4, Hnf4, Hnf4alpha, MODY1, Nr2a1, Tcf14, HNF4a7, HNF4a8, HNF4a9, MODY, NR2A1, NR2A21, TCF, TCF1 ... show more
HNF4A, HNF4alpha, CG9310, DmHNF4, Dmel\\CG9310, HNF-4, HNF-4(D), HNF4, Hnf-4, Hnf-4h, NR2A4, dHNF-4, dHNF4, Hnf4, Hnf4alpha, MODY1, Nr2a1, Tcf14, HNF4a7, HNF4a8, HNF4a9, MODY, NR2A1, NR2A21, TCF, TCF14, HNF-4alpha, fb58h09, id:ibd1279, wu:fb58h09, hnf4, nr2a1 show less
Epitope
AA 324-424
(22), (19), (11), (9), (8), (7), (6), (4), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(132), (63), (62), (28), (26), (25), (24), (4), (1), (1)
Host
Mouse
(110), (19), (8)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunofluorescence (IF), Western Blotting (WB)
(116), (57), (26), (23), (20), (16), (15), (5), (4), (3), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394055
450.00 $
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Immunogen HNF4A (NP_000448, 324 a.a. ~ 424 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1F12
Isotype IgG2a kappa
Specificity HNF4A (NP_000448, 324 a.a. ~ 424 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HNF4A
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 52785 DA
Gene ID 12406
NCBI Accession NP_000448
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (AA 324-424) antibody Immunofluorescence of monoclonal antibody to HNF4A on HeLa cell (antibody concentration 10 µg/mL). HNF4A monoclonal antibody (M05), clone 1F12 Western Blot analysis of HNF4A expression in HeLa.
anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (AA 324-424) antibody (2) anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (AA 324-424) antibody (Image 2)
Background publications Ruchat, Vohl, Weisnagel et al.: "Combining genetic markers and clinical risk factors improves the risk assessment of impaired glucose metabolism." in: Annals of medicine, Vol. 42, Issue 3, pp. 196-206, 2010 (PubMed).

de Boussac, Ratajewski, Sachrajda et al.: "The ERK1/2-hepatocyte nuclear factor 4alpha axis regulates human ABCC6 gene expression in hepatocytes." in: The Journal of biological chemistry, Vol. 285, Issue 30, pp. 22800-8, 2010 (PubMed).

Chen, Zhang, Liu et al.: "Variants in hepatocyte nuclear factor 4alpha gene promoter region and type 2 diabetes risk in Chinese." in: Experimental biology and medicine (Maywood, N.J.), Vol. 235, Issue 7, pp. 857-61, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Jablonski, McAteer, de Bakker et al.: "Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program." in: Diabetes, Vol. 59, Issue 10, pp. 2672-81, 2010 (PubMed).

Validation Images
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