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Retinoic Acid Receptor, beta (RARB) (AA 1-100) antibody

Details for Product No. ABIN394068
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Antigen
Synonyms RARB, nRARs, HAP, NR1B2, RRB2, A830025K23, Hap, Nr1b2, RARbeta2, RARBETA
Epitope
AA 1-100
(22), (11), (7), (7), (6), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(80), (32), (16), (15), (13), (12), (12), (1), (1)
Host
Mouse
(72), (12)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(57), (29), (21), (17), (10), (6), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394068
450.00 $
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Immunogen RARB (AAH60794, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1F7
Isotype IgG2a kappa
Specificity RARB (AAH60794, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name RARB
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 50489 DA
Gene ID 12406
Research Area Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants, one additional transcript has been described, but its full length nature has not been determined.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Retinoic Acid Receptor, beta (RARB) (AA 1-100) antibody Detection limit for recombinant GST tagged RARB is approximately 0.1 ng/mL as a capture antibody.
Background publications Kim, Choi, Lee et al.: "Quantitative assessment of DNA methylation for the detection of cervical neoplasia in liquid-based cytology specimens." in: Virchows Archiv : an international journal of pathology, Vol. 457, Issue 1, pp. 35-42, 2010 (PubMed).

Ding, Chen, Yan et al.: "Association analysis of retinoic acid receptor beta (RARbeta) gene with high myopia in Chinese subjects." in: Molecular vision, Vol. 16, pp. 855-61, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Validation Images
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