Retinoic Acid Receptor, beta (RARB) antibody

Antigen: Retinoic Acid Receptor, beta (RARB)

Synonyms: HAP, RRB2, NR1B2, RXR-beta, RARBETA, RARB, nRARs

Clonality: Monoclonal (1F7)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN394068

Additional Information

Alternative name: RARB

Gene ID: 5915

Immunogen: RARB (AAH60794, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 1F7

Description: Other names: HAP, NR1B2, RRB2 retinoic acid receptor, beta

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: RARB (AAH60794, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 50489 DA

Comments:

Background: This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants, one additional transcript has been described, but its full length nature has not been determined.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cancer, Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged RARB is approximately 0.1ng/ml as a capture antibody.

Publications

Product: Kim, Choi, Lee et al.: "Quantitative assessment of DNA methylation for the detection of cervical neoplasia in liquid-based cytology specimens." in: Virchows Archiv : an international journal of pathology, Vol. 457, Issue 1, pp. 35-42, 2010 (PubMed).

Ding, Chen, Yan et al.: "Association analysis of retinoic acid receptor beta (RARbeta) gene with high myopia in Chinese subjects." in: Molecular vision, Vol. 16, pp. 855-61, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).