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TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, A, 48kDa (TAF1A) (AA 1-101) antibody

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Synonyms TAFI48, mTAFI48, MGC:17061, RAFI48, SL1
AA 1-101
(21), (16), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
(41), (8), (2), (2), (1)
(39), (3)
Clonality (Clone)
Monoclonal ()
(2), (2), (2), (2), (2), (2)
ELISA, Western Blotting (WB)
(40), (25), (2), (1)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen TAF1A (NP_005672, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1F8
Isotype IgG2a kappa
Specificity TAF1A (NP_005672, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TAF1A (TAF1A Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 52676 DA
Gene ID 12406
NCBI Accession NP_005672
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, A, 48kDa (TAF1A) (AA 1-101) antibody (ABIN394070) Detection limit for recombinant GST tagged TAF1A is approximately 0.1 ng/mL as a capt...
Background publications Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Greco-Stewart, Schissel, Pelchat: "The hepatitis delta virus RNA genome interacts with the human RNA polymerases I and III." in: Virology, Vol. 386, Issue 1, pp. 12-5, 2009 (PubMed).

Young, Hassan, Pratap et al.: "Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2." in: Nature, Vol. 445, Issue 7126, pp. 442-6, 2007 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Grandori, Gomez-Roman, Felton-Edkins et al.: "c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I." in: Nature cell biology, Vol. 7, Issue 3, pp. 311-8, 2005 (PubMed).

Catalog No. ABIN394070
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