Caveolin 3 antibody (CAV3) (AA 1-84)

Details for Product anti-CAV3 Antibody No. ABIN394074, Supplier: Log in to see
Antigen
  • caveolin-3
  • cav-3
  • cav3
  • im:6902906
  • zgc:109710
  • LOC733765
  • CAV3
  • Cav-3
  • LGMD1C
  • LQT9
  • VIP-21
  • VIP21
  • AI385751
  • M-cav
  • caveolin-3-like
  • caveolin 3
  • caveolin 3, gene 2
  • caveolin 3, gene 1
  • caveolin-3
  • Caveolin-3
  • LOC100058881
  • CAV3
  • cav3.2
  • cav3
  • LOC733765
  • cav3.1
  • Cav-3
  • Cav3
Alternatives
anti-Human Caveolin 3 antibody for ELISA
Epitope
AA 1-84
24
6
5
3
3
3
2
1
1
1
1
1
1
1
1
Reactivity
Human
55
29
28
11
8
7
5
5
5
3
3
2
1
1
Host
Mouse
33
18
9
Clonality (Clone)
Monoclonal ()
Conjugate
This Caveolin 3 antibody is un-conjugated
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
54
24
21
15
8
5
5
3
2
1
Options
Supplier
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Immunogen CAV3 (NP_001225, 1 a.a. ~ 84 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1G11
Isotype IgG2b kappa
Specificity CAV3 (NP_001225, 1 a.a. ~ 84 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CAV3 (CAV3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 17259 DA
Gene ID 12406
NCBI Accession NP_001225
Research Area Translation Factors, Cell Structure, Signaling
Pathways Carbohydrate Homeostasis, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Caveolin 3 antibody (CAV3) (AA 1-84) (ABIN394074) Detection limit for recombinant GST tagged CAV3 is approximately 1 ng/mL as a capture...
Background publications Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Roberts, Kawut, Krowka, Brown, Trotter, Shah, Peter, Tighiouart, Mitra, Handorf, Knowles, Zacks, Fallon,: "Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease." in: Gastroenterology, Vol. 139, Issue 1, pp. 130-9.e24, 2010 (PubMed).

Sundblom, Stålberg, Osterdahl, Rücker, Montelius, Kalimo, Nennesmo, Islander, Smits, Dahl, Melberg: "Bedside diagnosis of rippling muscle disease in CAV3 p.A46T mutation carriers." in: Muscle & nerve, Vol. 41, Issue 6, pp. 751-7, 2010 (PubMed).

Joslyn, Ravindranathan, Brush, Schuckit, White: "Human variation in alcohol response is influenced by variation in neuronal signaling genes." in: Alcoholism, clinical and experimental research, Vol. 34, Issue 5, pp. 800-12, 2010 (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).