Caveolin 3 (CAV3) antibody

Antigen: Caveolin 3 (CAV3)

Synonyms: LQT9, VIP21, LGMD1C, VIP-21, MGC126100, MGC126101, MGC126129, Cav-3, M-cav, AI385751, M-caveolin, caveolin-3, MGC105449, cav3, MGC53569, im:6902906, zgc:109710, CAV3, MGC137366, LOC733765, cav-3

Clonality: Monoclonal (1G11)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN394074

Additional Information

Alternative name: CAV3

Gene ID: 859

UniProt: NP_001225

Immunogen: CAV3 (NP_001225, 1 a.a. ~ 84 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2b kappa

Clone: 1G11

Description: Other names: LGMD1C, MGC126100, MGC126101, MGC126129, VIP21, VIP21 caveolin 3

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: CAV3 (NP_001225, 1 a.a. ~ 84 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 17259 DA

Comments:

Background: This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Translation Factors, Cell Structure, Signaling

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged CAV3 is approximately 1ng/ml as a capture antibody.

Publications

Product: Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Joslyn, Ravindranathan, Brush et al.: "Human variation in alcohol response is influenced by variation in neuronal signaling genes." in: Alcoholism, clinical and experimental research, Vol. 34, Issue 5, pp. 800-12, 2010 (PubMed).

Sundblom, Stålberg, Osterdahl et al.: "Bedside diagnosis of rippling muscle disease in CAV3 p.A46T mutation carriers." in: Muscle & nerve, Vol. 41, Issue 6, pp. 751-7, 2010 (PubMed).

Roberts, Kawut, Krowka et al.: "Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease." in: Gastroenterology, Vol. 139, Issue 1, pp. 130-9.e24, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).