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Testis Derived Transcript (3 LIM Domains) (TES) (AA 1-422) antibody

Details for Product No. ABIN394077
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Antigen
Synonyms zgc:92091, tess, tess-2, xtes, TES, DKFZp469E2320, Testin, D6Ertd352e, TESS, Tes1, Tes2, testin2, TESS-2
Epitope
AA 1-422
(9), (8), (7), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(28), (15), (15), (12), (12)
Host
Mouse
(29), (10), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(31), (18), (10), (7), (6), (6), (3)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394077
450.00 $
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Immunogen TES (AAH01451, 1 a.a. ~ 422 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1G11-B7
Isotype IgG1 kappa
Specificity TES (AAH01451, 1 a.a. ~ 422 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TES
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 47996 DA
Gene ID 12406
Research Area Cell Signaling, Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. Multiple protein isoforms are encoded by transcript variants of this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Testis Derived Transcript (3 LIM Domains) (TES) (AA 1-422) antibody Immunofluorescence of monoclonal antibody to TES on HeLa cell (antibody concentration 10 µg/mL). Western Blot analysis of TES expression in transfected 293T cell line by TES monoclonal antibody (M01), clone 1G11-B7. Lane 1: TES transfected lysate(48 KDa). Lane 2: Non-transfected lysate.
anti-Testis Derived Transcript (3 LIM Domains) (TES) (AA 1-422) antibody (2) anti-Testis Derived Transcript (3 LIM Domains) (TES) (AA 1-422) antibody (Image 2)
Background publications Boëda, Briggs, Higgins et al.: "Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding." in: Molecular cell, Vol. 28, Issue 6, pp. 1071-82, 2007 (PubMed).

Zhong, Zhu, Wang et al.: "LIM domain protein TES changes its conformational states in different cellular compartments." in: Molecular and cellular biochemistry, Vol. 320, Issue 1-2, pp. 85-92, 2008 (PubMed).

Huang, Weng, Pan et al.: "[Expression and clinical significance of TESTIN in primary gastric cancer]." in: Ai zheng = Aizheng = Chinese journal of cancer, Vol. 27, Issue 9, pp. 984-8, 2008 (PubMed).

Gunduz, Gunduz, Beder et al.: "Downregulation of TESTIN and its association with cancer history and a tendency toward poor survival in head and neck squamous cell carcinoma." in: Archives of otolaryngology--head & neck surgery, Vol. 135, Issue 3, pp. 254-60, 2009 (PubMed).

Qiu, Zhu, Yuan et al.: "Frequent hypermethylation and loss of heterozygosity of the testis derived transcript gene in ovarian cancer." in: Cancer science, Vol. 101, Issue 5, pp. 1255-60, 2010 (PubMed).

Validation Images
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