Testis Derived Transcript (3 LIM Domains) (TES) antibody

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Synonyms TESS, TESS-2, D6Ertd352e, Tes1, Tes2, testin2, Testin, tess, tess-2, zgc:92091, xtes, TES, DKFZp469E2320
(16), (16), (16), (12), (12)
(23), (4), (1)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(18), (10), (9), (6), (3), (1), (1)
Pubmed 5 references available
Catalog no. ABIN394077
Quantity 0.1 mg
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Immunogen TES (AAH01451, 1 a.a. ~ 422 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1G11-B7
Isotype IgG1 kappa
Specificity TES (AAH01451, 1 a.a. ~ 422 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TES
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 47996 DA
Gene ID 12406
Research Area Cell Signaling, Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000

Background: Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. Multiple protein isoforms are encoded by transcript variants of this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Testis Derived Transcript (3 LIM Domains) (TES) antibody Immunofluorescence of monoclonal antibody to TES on HeLa cell (antibody concentration 10 µg/mL). Western Blot analysis of TES expression in transfected 293T cell line by TES monoclonal antibody (M01), clone 1G11-B7. Lane 1: TES transfected lysate(48 KDa). Lane 2: Non-transfected lysate.
anti-Testis Derived Transcript (3 LIM Domains) (TES) antibody (2) anti-Testis Derived Transcript (3 LIM Domains) (TES) antibody (Image 2)
Background publications Boëda, Briggs, Higgins et al.: "Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding." in: Molecular cell, Vol. 28, Issue 6, pp. 1071-82, 2007 (PubMed).

Zhong, Zhu, Wang et al.: "LIM domain protein TES changes its conformational states in different cellular compartments." in: Molecular and cellular biochemistry, Vol. 320, Issue 1-2, pp. 85-92, 2008 (PubMed).

Huang, Weng, Pan et al.: "[Expression and clinical significance of TESTIN in primary gastric cancer]." in: Ai zheng = Aizheng = Chinese journal of cancer, Vol. 27, Issue 9, pp. 984-8, 2008 (PubMed).

Gunduz, Gunduz, Beder et al.: "Downregulation of TESTIN and its association with cancer history and a tendency toward poor survival in head and neck squamous cell carcinoma." in: Archives of otolaryngology--head & neck surgery, Vol. 135, Issue 3, pp. 254-60, 2009 (PubMed).

Qiu, Zhu, Yuan et al.: "Frequent hypermethylation and loss of heterozygosity of the testis derived transcript gene in ovarian cancer." in: Cancer science, Vol. 101, Issue 5, pp. 1255-60, 2010 (PubMed).

Hosts (23), (4), (1)
Reactivities (16), (16), (16), (12), (12)
Applications (18), (10), (9), (6), (3), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2), (2), (2), (1), (1)
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