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Details for Product No. ABIN394077

Testis Derived Transcript (3 LIM Domains) (TES) antibody

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Antigen
Synonyms TESS, TESS-2, D6Ertd352e, Tes1, Tes2, testin2, Testin, tess, tess-2, zgc:92091, xtes, TES, DKFZp469E2320
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN394077
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen TES (AAH01451, 1 a.a. ~ 422 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1G11-B7
Isotype IgG1 kappa
Specificity TES (AAH01451, 1 a.a. ~ 422 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TES
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 47996 DA
Gene ID 12406
Research Area Cell Signaling, Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml Immunofluorescence
Comment

Background: Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. Multiple protein isoforms are encoded by transcript variants of this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Boëda, Briggs, Higgins et al.: "Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding." in: Molecular cell, Vol. 28, Issue 6, pp. 1071-82, 2007 (PubMed).

Zhong, Zhu, Wang et al.: "LIM domain protein TES changes its conformational states in different cellular compartments." in: Molecular and cellular biochemistry, Vol. 320, Issue 1-2, pp. 85-92, 2008 (PubMed).

Huang, Weng, Pan et al.: "[Expression and clinical significance of TESTIN in primary gastric cancer]." in: Ai zheng = Aizheng = Chinese journal of cancer, Vol. 27, Issue 9, pp. 984-8, 2008 (PubMed).

Gunduz, Gunduz, Beder et al.: "Downregulation of TESTIN and its association with cancer history and a tendency toward poor survival in head and neck squamous cell carcinoma." in: Archives of otolaryngology--head & neck surgery, Vol. 135, Issue 3, pp. 254-60, 2009 (PubMed).

Qiu, Zhu, Yuan et al.: "Frequent hypermethylation and loss of heterozygosity of the testis derived transcript gene in ovarian cancer." in: Cancer science, Vol. 101, Issue 5, pp. 1255-60, 2010 (PubMed).

Alternatives for antigen "Testis Derived Transcript (3 LIM Domains) (TES)", type "Antibodies"
Hosts (21), (4), (1)
Reactivities (14), (14), (13), (12), (12)
Applications (16), (10), (9), (6), (3), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (2), (2), (2), (2), (1), (1)
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