Upstream Transcription Factor 1 (USF1) (AA 1-111) antibody

Details for Product No. ABIN394103
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Antigen
Synonyms zgc:56547, USF1, uef, fchl, mltf, fchl1, mltfi, hyplip1, DKFZp469G215, usf1, bhlhb11, FCHL, FCHL1, HYPLIP1, MLTF, MLTFI, UEF, bHLHb11, rUSF1a
Epitope
AA 1-111
(3), (2), (2), (2), (2), (2), (1)
Reactivity
Human
(38), (26), (21), (15), (15), (15), (13), (3), (2)
Host
Mouse
(32), (6)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(29), (11), (10), (9), (4), (4), (3), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394103
450.00 $
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Immunogen USF1 (NP_009053, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2A7
Isotype IgG1 kappa
Specificity USF1 (NP_009053, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name USF1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 33538 DA
Gene ID 12406
NCBI Accession NP_009053
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Upstream Transcription Factor 1 (USF1) (AA 1-111) antibody USF1 monoclonal antibody (M02), clone 2A7 Western Blot analysis of USF1 expression in MCF-7. Detection limit for recombinant GST tagged USF1 is approximately 0.1 ng/mL as a capture antibody.
anti-Upstream Transcription Factor 1 (USF1) (AA 1-111) antibody (2) anti-Upstream Transcription Factor 1 (USF1) (AA 1-111) antibody (Image 2)
Background publications Wu, Mar-Heyming, Dugum et al.: "Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice." in: Human molecular genetics, Vol. 19, Issue 4, pp. 597-608, 2010 (PubMed).

Naukkarinen, Nilsson, Koistinen et al.: "Functional variant disrupts insulin induction of USF1: mechanism for USF1-associated dyslipidemias." in: Circulation. Cardiovascular genetics, Vol. 2, Issue 5, pp. 522-9, 2009 (PubMed).

Singmann, Baumert, Herder et al.: "Gene-gene interaction between APOA5 and USF1: two candidate genes for the metabolic syndrome." in: Obesity facts, Vol. 2, Issue 4, pp. 235-42, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Jablonski, McAteer, de Bakker et al.: "Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program." in: Diabetes, Vol. 59, Issue 10, pp. 2672-81, 2010 (PubMed).

Validation Images
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