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T-Complex 1 (TCP1) (AA 1-557) antibody

Details for Product No. ABIN394111, Supplier: Log in to see
Antigen
  • BEST:GH05123
  • CCT1
  • CG5374
  • Dmel\\CG5374
  • T-cpl
  • TCP-1alpha
  • TCPA_DROME
  • Tcp-1
  • Tcp1
  • Tcp1-alpha
  • gh05123
  • Cct1-1P
  • CCT-alpha
  • CCTa
  • D6S230E
  • TCP-1-alpha
  • CCT
  • TRiC
  • CCTalpha
  • AI528772
  • Cct1
  • Ccta
  • TRic
  • Tp63
  • c-cpn
  • p63
Epitope
AA 1-557
97
2
2
1
1
1
1
1
1
Reactivity
Human
100
74
59
40
39
39
37
20
19
19
18
18
18
18
1
1
1
Host
Mouse
80
34
18
4
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
6
6
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
120
81
61
60
38
37
22
11
9
2
1
Supplier
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Immunogen TCP1 (AAH00665, 1 a.a. ~ 557 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2B2-D6
Isotype IgG1 kappa
Specificity TCP1 (AAH00665, 1 a.a. ~ 557 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TCP1 (TCP1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 60344 DA
Gene ID 12406
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-T-Complex 1 (TCP1) (AA 1-557) antibody (ABIN394111) Immunofluorescence of monoclonal antibody to TCP1 on HeLa cell (antibody concentratio...
Immunohistochemistry (IHC) image for anti-T-Complex 1 (TCP1) (AA 1-557) antibody (ABIN394111) anti-T-Complex 1 (TCP1) (AA 1-557) antibody (Image 2)
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Mukherjee, Conway de Macario, Macario et al.: "Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes." in: BMC evolutionary biology, Vol. 10, pp. 64, 2010 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Ridsdale, Tseu, Wang et al.: "Functions of membrane binding domain of CTP:phosphocholine cytidylyltransferase in alveolar type II cells." in: American journal of respiratory cell and molecular biology, Vol. 43, Issue 1, pp. 74-87, 2010 (PubMed).

Burgner, Davila, Breunis et al.: "A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease." in: PLoS genetics, Vol. 5, Issue 1, pp. e1000319, 2009 (PubMed).